What is the distance between Rome and Lyon?

The distance between Rome and Lyon is approximately 748 km (464 miles).

What are the departure and arrival locations for buses traveling from Rome to Lyon?

Buses departing from Rome Tiburtina Bus Station in Rome will take you to Perrache in Lyon.

Bus Rome to Lyon from $48 | Refundable Tickets

Next bus departures

Next departures for Rome to Lyon on November 19
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	CheapestFastest
Bus	1:00pm	Rome Tiburtina Bus Station	2d 1h	2:50pm	de Perrache - Galerie A	No tags
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	No tags
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	No tags
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	No tags

Next departures for Rome to Lyon on November 20
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	7:45am	Rome Tiburtina Bus Station	14h 55m	10:40pm	Perrache	Cheapest
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	Fastest
Bus	12:10am	Rome Tiburtina Bus Station	16h 5m	4:15pm	Perrache	No tags
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	No tags
Bus	12:15am	Rome Tiburtina Bus Station	21h	9:15pm	Perrache	No tags

Next departures for Rome to Lyon on November 21
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	CheapestFastest
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	No tags
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	No tags
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	No tags
Bus	9:45pm	Rome Tiburtina Bus Station	15h 10m	12:55pm	Lyon Lyon Perrache Bus Station	No tags

Next departures for Rome to Lyon on November 22
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	CheapestFastest
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	No tags
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	No tags
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	No tags
Bus	9:45pm	Rome Tiburtina Bus Station	15h 10m	12:55pm	Lyon Lyon Perrache Bus Station	No tags

Next departures for Rome to Lyon on November 23
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	9:45pm	Rome Tiburtina Bus Station	15h 10m	12:55pm	Lyon Lyon Perrache Bus Station	Cheapest
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	Fastest
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	No tags
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	No tags
Bus	7:00am	Rome Tiburtina Bus Station	14h 30m	9:30pm	Lyon Lyon Perrache Bus Station	No tags

Last refresh of the prices: Last Monday at 1:00 PM CET.

Compare 3 ways to go from Rome to Lyon

We recommend carpooling

Among the sustainable travel choices, the carpool stands out as a good way to reach Lyon. The journey takes about 11 hours 40 minutes, and with fares starting at just $138, it presents an excellent value for a comfortable ride.

1carpool per day

11h 40mAverage Duration

748 kmDistance

31kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions
Bus	Average Price$48 - $389	Average Duration17h 10m	CO₂ emissions 19kg CO₂e
Train	Average Price$209 - $575	Average Duration8h 12m	CO₂ emissions 18kg CO₂e
Carpool	Average Price$138 - $138	Average Duration11h 40m	CO₂ emissions 31kg CO₂e

Compare bus companies

FlixBus

3.5/511,367 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Itabus

4/5944 reviews

Staff4.3

Timeliness3

Cleanliness4.3

Wifi3.1

BlaBlaCar Bus

3.5/511,138 reviews

Staff4.4

Timeliness3.6

Cleanliness4.3

Wifi2.6

RegioJet

4/51,057 reviews

Staff4.5

Timeliness3.9

Cleanliness4.4

Wifi3.8

FR Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Rede Expressos, Trenitalia

Where are the popular stops in Rome and Lyon?

Stops in Rome

A - Rome Tiburtina Bus Station

B - Rome Ciampino Airport

C - Rome Fiumicino Airport

D - Castro Pretorio

E - Roma

F - Anagnina

Stops in Lyon

A - Perrache

B - Lyon Airport

C - Lyon

D - Quai de Saoune

E - Villeurbanne INSA

F - Les Charrières

Frequently asked questions about travelling from Rome to Lyon by bus

What is the distance between Rome and Lyon?
The distance between Rome and Lyon is approximately 748 km (464 miles).
What are the departure and arrival locations for buses traveling from Rome to Lyon?
Buses departing from Rome Tiburtina Bus Station in Rome will take you to Perrache in Lyon.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-17

$77

11-18

$94

Today

$86

11-20

$53

11-21

$67

11-22

$67

11-23

$86

11-24

$58

The cheapest trip from Rome to Lyon was searched and found on Nov 20, 2025 with a price of $53

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Lyon, as early as possible.

You can expect to pay from $53 to $222 for a bus ticket from Rome to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at $53 which is on 2025-11-20.