Last refresh of the prices: Last Monday at 1:00 PM CET.
Compare 3 ways to go from Rome to Lyon
We recommend carpooling
Among the sustainable travel choices, the carpool stands out as the good way to reach Lyon. The journey takes about 11 hours 40 minutes and with fares starting at just $96, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Based on 944 reviews, the company was rated 3.8 stars on Busbud. Travelers were especially satisfied with the ticket access and the temperature but often complained with the timeliness. Itabus ticket prices on this trip start at $33
Based on 11138 reviews, the company was rated 3.7 stars on Busbud. Travelers were especially satisfied with the ticket access and the staff but often complained with the wifi. BlaBlaCar Bus ticket prices on this trip start at $49
Based on 1057 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the departure location and the value for money but often complained with the wifi. RegioJet ticket prices on this trip start at $156
Frequently asked questions about traveling from Rome to Lyon by bus
What is the distance between Rome and Lyon?
Rome and Lyon are 464 miles (748 km) apart.
What are the departure and arrival stations when taking the bus from Rome to Lyon?
If you're headed to Lyon from Rome, chances are that your bus will depart from Rome Tiburtina Bus Station and arrive at Perrache. These are the primary departure and arrival locations on this route, but you can find others that could fit better into your travel plans.
What are the best sights and things to do in Lyon?
Once in Lyon, you can start exploring the city and discover its surroundings. The top sights and things to do are Musée des Beaux Arts, Musée d’Art Contemporain, Opéra de Lyon, Institut Lumière and Musée des Tissus.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/17
$54
11/18
$66
Today
$60
11/20
$47
11/21
$47
11/22
$47
11/23
$60
11/24
$41
The cheapest trip from Rome to Lyon was searched and found on Nov 24, 2025 with a price of $41
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Lyon, as early as possible.
You can expect to pay from $41 to $155 for a bus ticket from Rome to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at $41 which is on 2025-11-24.
The cheapest trip from Rome to Lyon was searched and found on Nov 24, 2025 with a price of $41
