Bus Tickets from San Francisco to San Luis

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TodayMay 11
from US$40
TomorrowMay 12
TueMay 13
WedMay 14
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FriMay 16
SatMay 17
SunMay 18

Cheap buses leaving today

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: May 11 at
    Departure city: San Francisco
    Departure location: Terminal San Francisco
    Arrival time: May 12 at
    Destination city: San Luis
    Destination location: Estación de Interconexión Regional de Ómnibus de San Luis
    Operated by: La 20 de JunioLa 20 de Junio
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: May 11 at
    Departure city: San Francisco
    Departure location: Terminal San Francisco
    Arrival time: May 12 at
    Destination city: San Luis
    Destination location: Estación de Interconexión Regional de Ómnibus de San Luis
    Operated by: AndesmarAndesmar
    Vehicle: BusDuration:
  • Departure time: May 11 at
    Departure city: San Francisco
    Departure location: Terminal San Francisco
    Arrival time: May 12 at
    Destination city: San Luis
    Destination location: Estación de Interconexión Regional de Ómnibus de San Luis
    Operated by: La 20 de JunioLa 20 de Junio
    Vehicle: BusDuration:
  • Departure time: May 11 at
    Departure city: San Francisco
    Departure location: Terminal San Francisco
    Arrival time: May 12 at
    Destination city: San Luis
    Destination location: Estación de Interconexión Regional de Ómnibus de San Luis
    Operated by: AndesmarAndesmar
    Vehicle: BusDuration:
  • Departure time: May 11 at
    Departure city: San Francisco
    Departure location: Terminal San Francisco
    Arrival time: May 12 at
    Destination city: San Luis
    Destination location: Estación de Interconexión Regional de Ómnibus de San Luis
    Operated by: AndesmarAndesmar
    Vehicle: BusDuration:

Last refresh of the prices: Last Friday at 8:20 PM -03.

Prices and availability are subject to change.

Accepted payments

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Bus San Francisco to San Luis: Trip Overview

Average Ticket PriceUS$48
Average Bus Trip Duration8h 40m
Number of daily buses1
Earliest bus departure11:10pm
Distance446 km

San Francisco to San Luis Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from San Francisco to San Luis.

We make sure you can find a bus service from San Francisco to San Luis from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to San Luis from San Francisco, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip San Francisco - San Luis

  1. How long does it take to get to San Luis from San Francisco by bus?

    The trip from San Francisco to San Luis will take on average 8h 40m. The fastest bus on this trip will get to San Luis in 8h 40m

  2. What is the distance between San Francisco and San Luis?

    The distance between San Francisco and San Luis is approximately 450 km (279 miles).

  3. What are the departure and arrival locations for buses traveling from San Francisco to San Luis?

    Buses departing from Terminal San Francisco in San Francisco will take you to Estación de Interconexión Regional de Ómnibus de San Luis in San Luis.

  4. What is the cheapest way to travel from San Francisco to San Luis?

    Taking the bus is the most budget-friendly option to travel from San Francisco to San Luis. The ticket price for this bus starts at US$48, making this your best choice for this trip.

  5. How much is the bus from San Francisco to San Luis?

    You can expect to pay around US$48 for the bus ride from San Francisco to San Luis.

  6. Is it possible to travel by overnight bus from San Francisco to San Luis?

    Yes! If you're heading from San Francisco to San Luis, you'll find buses departing until 11:10pm and arriving the next day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
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Today
US$36
05-12
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busbud logoThe cheapest trip from San Francisco to San Luis was searched and found on May 11, 2025 with a price of US$36

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Francisco to San Luis, as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from San Francisco to San Luis but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Francisco to San Luis, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from San Francisco to San Luis.

Make a music playlist for your bus ride from San Francisco to San Luis, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to San Francisco by bus?

Bus from San Francisco to San Luis

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