Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | San Ysidro Bus terminal | Lafayette Bus Stop | CheapestFastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | San Ysidro Bus terminal | Lafayette Bus Stop | No tags | ||||
 | Bus | San Ysidro Bus terminal | Lafayette Bus Stop | No tags |
Last refresh of the prices: Today at 5:16 PM PST.
Get from San Ysidro to Lafayette
The journey takes about 2 days, 6 hours 25 minutes, and with fares starting at just $357, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Ysidro and Lafayette?
Stops in Lafayette
- A
CityBus Center
N 3rd St & North St (Corner), Lafayette, IN 47901
Compare bus companies
Based on 87478 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $357
Frequently asked questions about travelling from San Ysidro, CA to Lafayette, IN by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from San Ysidro to Lafayette?
The cheapest bus tickets from San Ysidro to Lafayette start from $357. The average price for this route is around $377. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Ysidro to Lafayette?
The average bus travel time from San Ysidro to Lafayette is 2d 6h, covering a distance of 2818 km. The quickest bus can get you there in 2d 6h and is operated by Greyhound.
Which bus companies service the San Ysidro to Lafayette route?
Several major bus companies operate on this route with 3 buses available per day.
What are the earliest and latest departure times for the bus from San Ysidro to Lafayette?
The earliest bus departs from San Ysidro to Lafayette at 9:25am. And the latest bus departs at 7:00pm.
What are the CO₂ emissions for the bus trip from San Ysidro to Lafayette?
A bus trip from San Ysidro to Lafayette generates an estimated 70 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Ysidro, CA to Lafayette, IN was searched and found on Jan 6, 2026 with a price of $332To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Ysidro, CA to Lafayette, IN, as early as possible.
You can expect to pay from $332 to $332 for a bus ticket from San Ysidro, CA to Lafayette, IN based on the last 2 days. You can expect to find the cheapest price for the trip at $332 which is on 2026-01-06.
