Bus Tickets from Santa Fe, AR to San Luis, AR

Find affordable bus tickets from Santa Fe, AR to San Luis, AR with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayJun 23
TomorrowJun 24
from US$56
WedJun 25
ThuJun 26
FriJun 27
SatJun 28
SunJun 29
MonJun 30

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: June 24 at
    Departure city: Santa Fe
    Departure location: Estación Terminal de Ómnibius, Santa Fe
    Arrival time: June 24 at
    Destination city: San Luis
    Destination location: Estación de Interconexión Regional de Ómnibus de San Luis
    Operated by: La 20 de JunioLa 20 de Junio
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: June 24 at
    Departure city: Santa Fe
    Departure location: Estación Terminal de Ómnibius, Santa Fe
    Arrival time: June 24 at
    Destination city: San Luis
    Destination location: Estación de Interconexión Regional de Ómnibus de San Luis
    Operated by: Flecha BusFlecha Bus
    Vehicle: BusDuration:
  • Departure time: June 24 at
    Departure city: Santa Fe
    Departure location: Estación Terminal de Ómnibius, Santa Fe
    Arrival time: June 24 at
    Destination city: San Luis
    Destination location: Estación de Interconexión Regional de Ómnibus de San Luis
    Operated by: La 20 de JunioLa 20 de Junio
    Vehicle: BusDuration:
  • Departure time: June 24 at
    Departure city: Santa Fe
    Departure location: Estación Terminal de Ómnibius, Santa Fe
    Arrival time: June 24 at
    Destination city: San Luis
    Destination location: Estación de Interconexión Regional de Ómnibus de San Luis
    Operated by: Flecha BusFlecha Bus
    Vehicle: BusDuration:
  • Departure time: June 24 at
    Departure city: Santa Fe
    Departure location: Estación Terminal de Ómnibius, Santa Fe
    Arrival time: June 25 at
    Destination city: San Luis
    Destination location: Estación de Interconexión Regional de Ómnibus de San Luis
    Operated by: AndesmarAndesmar
    Vehicle: BusDuration:

Last refresh of the prices: Yesterday at 9:49 PM -03.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Santa Fe to San Luis: Trip Overview

Average Ticket PriceUS$58
Average Bus Trip Duration11h 45m
Number of daily buses4
Earliest bus departure2:00am
Distance556 km
Latest bus departure9:00pm

Santa Fe to San Luis Bus

Busbud helps you find a bus from Santa Fe to San Luis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Santa Fe to San Luis.

Whether it is cheap bus tickets or more luxurious buses going to San Luis from Santa Fe, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Santa Fe, AR - San Luis, AR

  1. What is the distance between Santa Fe and San Luis?

    The distance between Santa Fe and San Luis is approximately 561 km (348 miles).

  2. What are the departure and arrival locations for buses traveling from Santa Fe to San Luis?

    Buses departing from Estación Terminal de Ómnibius, Santa Fe in Santa Fe will take you to Estación de Interconexión Regional de Ómnibus de San Luis in San Luis.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-21
US$52
06-22
No data
Today
No data
06-24
US$52
06-25
No data
06-26
No data
06-27
No data
06-28
No data
busbud logoThe cheapest trip from Santa Fe to San Luis was searched and found on Jun 24, 2025 with a price of US$52

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Fe to San Luis, as early as possible.

You can expect to pay from US$52 to US$66 for a bus ticket from Santa Fe to San Luis based on the last 2 days. You can expect to find the cheapest price for the trip at US$52 which is on 2025-06-24.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Santa Fe and San Luis!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Santa Fe to San Luis.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Santa Fe to San Luis.

Tune out to the fine sounds of your best music playlist on your bus trip from Santa Fe to San Luis while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to Santa Fe by bus?

Bus from Santa Fe to San Luis

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Santa Fe

Buses Leaving from Santa Fe

Buses Going to Santa Fe

Popular Buses Connecting San Luis

Buses Leaving from San Luis

Buses Going to San Luis