Bus Tickets from St. Louis to Gainesville, FL

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Previously seen trips

One passenger / one way

  • Departure time: September 5 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 5 at
    Destination city: Gainesville
    Destination location: Gainesville Bus Stop
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 6 at
    Destination city: Gainesville
    Destination location: Rosa Parks Station
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 6 at
    Destination city: Gainesville
    Destination location: Rosa Parks Station
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 6 at
    Destination city: Gainesville
    Destination location: Gainesville Bus Stop
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 7 at
    Destination city: Gainesville
    Destination location: Gainesville Bus Stop
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:

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Compare 2 ways to go from St. Louis to Gainesville

Bus
Average PriceUS$100 - US$213Average Duration20h 55m
31kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$371 - US$371Average Duration1d 23h
112kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from St. Louis to Gainesville

Among the sustainable travel choices, the bus stands out as a good way to reach Gainesville. The journey takes about 20 hours 55 minutes, and with fares starting at just US$100, it presents an excellent value for a comfortable ride.

7bus per day
20h 55mAverage Duration
US$100Cheapest ticket
31kgCO₂ emissions

Bus St. Louis to Gainesville, FL: Trip Overview

Average Ticket PriceUS$124
Average Bus Trip Duration20h 55m
Number of daily buses7
Earliest bus departure2:35am
Distance1225 km
Latest bus departure11:30pm

St. Louis to Gainesville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from St. Louis to Gainesville.

We make it our job to connect you with the most dependable bus companies that cover bus service from St. Louis to Gainesville.

From cheap bus tickets to more luxurious buses travelling from St. Louis to Gainesville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip St. Louis - Gainesville, FL

  1. What is the travel distance from St. Louis to Gainesville?

    St. Louis and Gainesville are 1234 km (765 miles) apart.

  2. What are the departure and arrival locations for buses traveling from St. Louis to Gainesville?

    Buses departing from Gateway Station in St. Louis will take you to Rosa Parks Station in Gainesville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-31
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09-01
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Today
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09-03
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09-04
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09-05
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09-06
US$104
09-07
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busbud logoThe cheapest trip from St. Louis to Gainesville, FL was searched and found on Sep 6, 2025 with a price of US$104

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Gainesville, FL, as early as possible.

You can expect to pay from US$104 to US$113 for a bus ticket from St. Louis to Gainesville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at US$104 which is on 2025-09-06.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from St. Louis to Gainesville but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from St. Louis to Gainesville.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St. Louis to Gainesville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from St. Louis to Gainesville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

What's the cheapest way to go from St. Louis to Gainesville, FL?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St. Louis by bus?

Bus from Gainesville, FL to St. Louis

Why choose Busbud?

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