Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Gateway Station | Old Town San Diego | CheapestFastest | ||||
| Train | Gateway Station | Santa Fe Depot | No tags | ||||
| Train | Gateway Station | Santa Fe Depot | No tags | ||||
| Train | Gateway Station | Santa Fe Depot | No tags | ||||
| Train | Gateway Station | Old Town San Diego | No tags |
Last refresh of the prices: Yesterday at 6:26 PM CST.
Compare 2 ways to go from St. Louis to San Diego
Among the sustainable travel choices, the bus stands out as a good way to reach San Diego. The journey takes about 1 day, 23 hours 40 minutes, and with fares starting at just $226, it presents an excellent value for a comfortable ride.
Train companies
Based on 5621 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $342
Frequently asked questions about travelling from St. Louis to San Diego, CA, US by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from St. Louis to San Diego?
The cheapest train tickets from St. Louis to San Diego start at $342. The average price for this train route is around $506. Busbud recommends booking your tickets in advance to increase your chances of getting the lowest possible price.
How long is the train ride from St. Louis to San Diego?
The average train trip from St. Louis to San Diego takes 2d 8h and covers 2514 km. The quickest train gets you there in 2d 8h and is operated by Amtrak.
Which train operators serve the St. Louis to San Diego route?
Several major train operators serve this route, with 2 trains available per day.
What are the earliest and latest departure times for the train from St. Louis to San Diego?
The earliest train from St. Louis to San Diego departs at 6:35am. The latest train departs at 7:42pm.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to San Diego, CA, US was searched and found on Dec 2, 2025 with a price of $328To save money and be sure you have the best seat, it's a good idea to buy your train tickets from St. Louis to San Diego, CA, US, as early as possible.
You can expect to pay from $328 to $2,256 for a train ticket from St. Louis to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $328 which is on 2025-12-05.
