Train from St. Louis to San Diego, CA, US: Tickets & Schedules
Next train departures
Next departures for St. Louis to San Diego on December 3
Operated by
Vehicle type
Departure time
Departure location
Trip duration
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Recommended
Price and booking link
Train
Gateway Station
Old Town San Diego
CheapestFastest
Train
Gateway Station
Santa Fe Depot
No tags
Train
Gateway Station
Santa Fe Depot
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Train
Gateway Station
Santa Fe Depot
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Train
Gateway Station
Old Town San Diego
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Last refresh of the prices: Yesterday at 6:26 PM CST.
Compare 2 ways to go from St. Louis to San Diego
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach San Diego. The journey takes about 1 day, 23 hours 40 minutes and with fares starting at just $158, it presents an excellent value for a comfortable ride.
Based on 5621 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $239
Frequently asked questions about traveling from St. Louis to San Diego, CA, US by train
How much does a train ticket from St. Louis to San Diego cost?
The average train ticket price from St. Louis to San Diego is $354. The best way to find train tickets from St. Louis to San Diego is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the train trip from St. Louis to San Diego?
A train trip between St. Louis and San Diego is around 2d 8h, although the fastest train will take about 2d 8h. This is the time it takes to travel the 1560 miles that separates the two cities.
How many daily trains are there between St. Louis and San Diego?
The number of trains from St. Louis to San Diego can differ depending on the day of the week. On average, there are 2. Some trains are direct while others have layovers. Simplify your train trip from St. Louis to San Diego by comparing and selecting the train that fits your travel style and budget on Busbud.
Which train companies travel from St. Louis to San Diego?
When taking the train from St. Louis to San Diego, you can travel comfortably and safely with Amtrak.
What are the best sights and things to do in San Diego?
Once in San Diego, you can explore the city. The top sights and things to do are Boat Tours in San Diego, San Diego Zoo, Coronado, Sunset Cliffs Natural Park, USS Midway Museum.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/30
$443
12/01
$1,415
Today
$229
12/03
$385
12/04
No data
12/05
$229
12/06
No data
12/07
No data
The cheapest trip from St. Louis to San Diego, CA, US was searched and found on Dec 2, 2025 with a price of $229
To save money and be sure you have the best seat, it's a good idea to buy your train tickets from St. Louis to San Diego, CA, US, as early as possible.
You can expect to pay from $229 to $1,575 for a train ticket from St. Louis to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $229 which is on 2025-12-05.
The cheapest trip from St. Louis to San Diego, CA, US was searched and found on Dec 2, 2025 with a price of $229
