Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Brookline | Bus station | Cheapest | ||||
 | Bus | Boston (South Station) | Bus station | Fastest | ||||
 | Bus | Boston (South Station) | Florence, SC | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Boston (South Station) | Florence, SC | No tags | ||||
| Bus | Brookline | Florence, SC | No tags |
Last refresh of the prices: Last Wednesday at 19:54 EST.
Compare 2 ways to travel from Boston to Florence
Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 18 hours and with fares starting at just £95, it presents an excellent value for a comfortable ride.
Where are the popular stops in Boston and Florence?
Stops in Boston
- A145 Dartmouth St, Boston, MA 02116, USA
- B100 Legends Way, Boston, MA 02114, USA
- C700 Atlantic Ave, Boston, MA 02205, USA
- D
Copley Square
115-127 St James Ave, Boston, MA 02116, USA - E
Prudential MBTA Station
220 Huntington Ave, Boston, MA 02115, USA - F
Copley MBTA Station
650 Boylston St, Boston, MA 02116, USA
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Frequently asked questions about travelling by bus from Boston, MA, US to Florence, SC, US
How far is Florence from Boston by coach?
The distance between Boston and Florence by coach is approximately 729 miles (1176 km).
Is there a way to reach Florence from Boston without flying?
You can choose the coach to travel this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You also have the option of utilising carpooling services.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Boston, MA, US to Florence, SC, US was searched and found on 20 Nov 2025 with a price of £98To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Florence, SC, US as early as possible.
You can expect to pay from £98 to £248 for a bus ticket from Boston, MA, US to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at £104, which is on 2025-11-27.
Usually Greyhound, FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Boston, MA, US to Florence, SC, US?
The bus is the cheapest travel choice for this destination
