Bus Tickets from Boston, MA, US to Florence, SC, US

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TodayJul 1
TomorrowJul 2
ThuJul 3
FriJul 4
from US$132
SatJul 5
SunJul 6
MonJul 7
from US$171
TueJul 8

Cheap buses leaving Friday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: July 4 at
    Departure city: Boston
    Departure location: 151 Steel Pl, Cambridge
    Arrival time: July 5 at
    Destination city: Florence
    Destination location: Bus station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: July 4 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: July 5 at
    Destination city: Florence
    Destination location: Bus station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 4 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: July 5 at
    Destination city: Florence
    Destination location: Bus station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 4 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: July 5 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

Last refresh of the prices: Last Friday at 4:16 PM EDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
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  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Boston to Florence

Bus
Average PriceUS$75 - US$244Average Duration19h 50m
30kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$239 - US$603Average Duration17h 30m
108kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the bus from Boston to Florence

Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 19 hours 50 minutes, and with fares starting at just US$75, it presents an excellent value for a comfortable ride.

3bus per day
19h 50mAverage Duration
US$75Cheapest ticket
30kgCO₂ emissions

Bus Boston to Florence: Trip Overview

Average Ticket PriceUS$143
Average Bus Trip Duration19h 50m
Number of daily buses3
Earliest bus departure9:00am
Distance1182 km
Latest bus departure5:15pm

Boston to Florence Bus

With Busbud, comparing and booking tickets for a bus from Boston to Florence is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Boston to Florence.

Whether it is cheap bus tickets or more luxurious buses going to Florence from Boston, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Boston, MA, US - Florence, SC, US

  1. What is the travel distance from Boston to Florence?

    It's about 1176 km (729 miles) from Boston to Florence.

  2. What are the departure and arrival locations for buses traveling from Boston to Florence?

    Buses traveling this route start their trip at Back Bay Station, in Boston, and end it at Florence Bus Station, in Florence.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-29
US$90
06-30
US$67
Today
US$148
07-02
No data
07-03
No data
07-04
No data
07-05
No data
07-06
No data
busbud logoThe cheapest trip from Boston to Florence was searched and found on Jun 30, 2025 with a price of US$67

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston to Florence, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Boston to Florence.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Boston to Florence.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Boston to Florence.

Make a music playlist for your bus ride from Boston to Florence, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

What's the cheapest way to go from Boston to Florence?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Boston by bus?

Bus from Boston to Florence

You can also go to Florence by train

Train from Boston to Florence

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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