What is the travel distance from Boston to Florence?

It's about 1176 km (729 miles) from Boston to Florence.

What are the departure and arrival locations for buses traveling from Boston to Florence?

Buses traveling this route start their trip at Back Bay Station, in Boston, and end it at Florence Bus Station, in Florence.

Bus Boston to Florence from $114 | Refundable Tickets

Next bus departures

Next departures for Boston to Florence on November 22
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	9:50pm	Boston (South Station)	1d 7h	5:45am	Florence, SC	Cheapest
	Bus	4:45pm	Boston (South Station)	19h	11:45am	Bus station	Fastest
	Bus	10:15am	Boston (South Station)	19h 30m	5:45am	Florence, SC	No tags
FlixBus + Greyhound Lines, Inc.	Bus	1:30am	Brookline	1d 10h	11:45am	Bus station	No tags
	Bus	1:30am	Brookline	1d 4h	5:45am	Florence, SC	No tags

Next departures for Boston to Florence on November 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	1:30am	Brookline	1d 10h	11:45am	Bus station	Cheapest
	Bus	4:45pm	Boston (South Station)	19h	11:45am	Bus station	Fastest
	Bus	10:15am	Boston (South Station)	19h 30m	5:45am	Florence, SC	No tags
FlixBus + Greyhound Lines, Inc.	Bus	9:50pm	Boston (South Station)	1d 7h	5:45am	Florence, SC	No tags
	Bus	1:30am	Brookline	1d 4h	5:45am	Florence, SC	No tags

Last refresh of the prices: Last Wednesday at 7:54 PM EST.

Compare 2 ways to go from Boston to Florence

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 18 hours, and with fares starting at just $175, it presents an excellent value for a comfortable ride.

10train per day

18hAverage Duration

1182 kmDistance

108kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$124 - $470	Average Duration1d 4h	CO₂ emissions 30kg CO₂e
Train	Average Price$175 - $1,179	Average Duration18h	CO₂ emissions 108kg CO₂e

Where are the popular stops in Boston and Florence?

Stops in Boston

A
Back Bay Station
145 Dartmouth St, Boston, MA 02116, USA
Visit page
B
North Station
100 Legends Way, Boston, MA 02114, USA
Visit page
C
South Station
700 Atlantic Ave, Boston, MA 02205, USA
Visit page
D
Copley Square
115-127 St James Ave, Boston, MA 02116, USA
E
Prudential MBTA Station
220 Huntington Ave, Boston, MA 02115, USA
F
Copley MBTA Station
650 Boylston St, Boston, MA 02116, USA

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Compare bus companies

FlixBus

3.5/511,391 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Greyhound

3.5/587,387 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from Boston, MA, US to Florence, SC, US by bus

What is the travel distance from Boston to Florence?
It's about 1176 km (729 miles) from Boston to Florence.
What are the departure and arrival locations for buses traveling from Boston to Florence?
Buses traveling this route start their trip at Back Bay Station, in Boston, and end it at Florence Bus Station, in Florence.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-19

$186

11-20

$181

Today

$225

11-22

$278

11-23

$229

11-24

$254

11-25

$339

11-26

$273

The cheapest trip from Boston, MA, US to Florence, SC, US was searched and found on Nov 20, 2025 with a price of $181

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Florence, SC, US, as early as possible.

You can expect to pay from $181 to $459 for a bus ticket from Boston, MA, US to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $229 which is on 2025-11-23.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.