Next bus departures

Next departures for Boston to Florence on September 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus Wi‑Fi Toilet Power outlets	4:45pm	Boston (South Station)	19h 14m	11:59am	Bus station	CheapestFastest
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	8:15pm	Boston (South Station)	20h 40m	4:55pm	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	1:30am	Brookline	1d 10h	11:59am	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	8:40pm	Brookline	20h 15m	4:55pm	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	11:00am	151 Steel Pl, Cambridge	1d	11:59am	Bus station	No tags

Next departures for Boston to Florence on September 22
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	11:00am	151 Steel Pl, Cambridge	1d	11:59am	Bus station	Cheapest
	Bus Wi‑Fi Toilet Power outlets	4:45pm	Boston (South Station)	19h 14m	11:59am	Bus station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	9:50pm	Boston (South Station)	1d 7h	5:45am	Florence, SC	No tags
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	11:00am	151 Steel Pl, Cambridge	1d 18h	5:45am	Florence, SC	No tags
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	8:15pm	Boston (South Station)	20h 40m	4:55pm	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	1:30am	Brookline	1d 10h	11:59am	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	8:40pm	Brookline	20h 15m	4:55pm	Bus station	No tags

Next departures for Boston to Florence on September 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	11:00am	151 Steel Pl, Cambridge	1d 13h	12:05am	Florence, SC	Cheapest
	Bus Wi‑Fi Toilet Power outlets	4:45pm	Boston (South Station)	19h 14m	11:59am	Bus station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus Wi‑Fi Toilet Power outlets	8:55am	Boston (South Station)	20h 50m	5:45am	Florence, SC	No tags
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	9:50pm	Boston (South Station)	1d 7h	5:45am	Florence, SC	No tags
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	1:30am	Brookline	1d 4h	5:45am	Florence, SC	No tags
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	8:40pm	Brookline	1d 9h	5:45am	Florence, SC	No tags
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	8:15pm	Boston (South Station)	20h 40m	4:55pm	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus Wi‑Fi Toilet Power outlets	1:30am	Brookline	1d 10h	11:59am	Bus station	No tags

Last refresh of the prices: Last Tuesday at 9:38 PM EDT.

Compare 2 ways to go from Boston to Florence

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Florence. The journey takes about 1 day, 59 minutes, and with fares starting at just $124, it presents an excellent value for a comfortable ride.

8bus per day

1d Average Duration

1181 kmDistance

30kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$124 - $338	Average Duration1d	CO₂ emissions 30kg CO₂e
Train	Average Price$222 - $898	Average Duration18h 10m	CO₂ emissions 107kg CO₂e

Bus stations and stops in Boston and Florence

Stops in Boston

A
Back Bay Station
145 Dartmouth St, Boston, MA 02116, USA
Visit page
B
North Station
100 Legends Way, Boston, MA 02114, USA
Visit page
C
Copley Square
115-127 St James Ave, Boston, MA 02116, USA
D
Prudential MBTA Station
220 Huntington Ave, Boston, MA 02115, USA
E
Copley MBTA Station
650 Boylston St, Boston, MA 02116, USA
F
Long Wharf
66 Long Wharf, Boston, MA 02110, USA

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Compare bus companies

FlixBus

3.5/515,785 reviews

Staff4.2

Timeliness4.0

Cleanliness4.1

Wi‑Fi2.7

Greyhound

3.5/588,157 reviews

Staff3.6

Timeliness3.0

Cleanliness3.4

Wi‑Fi2.5

US bus companies:FlixBus, Greyhound, Futura, Tufesa, Chihuahuenses, Adirondack Trailways, Valley Transit

Frequently asked questions about travelling from Boston, MA, US to Florence, SC, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Boston to Florence?
The cheapest bus tickets from Boston to Florence start from $124. The average price for this route is around $207. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Boston to Florence?
The average bus travel time from Boston to Florence is 1d , covering a distance of 1181 km. The quickest bus can get you there in 18h 45m and is operated by FlixBus.
Which bus companies service the Boston to Florence route?
Several major bus companies operate on this route with 8 buses available per day, including services from FlixBus, Greyhound.
What are the earliest and latest departure times for the bus from Boston to Florence?
The earliest bus departs from Boston to Florence at 1:30am. And the latest bus departs at 9:50pm.
What are the CO₂ emissions for the bus trip from Boston to Florence?
A bus trip from Boston to Florence generates an estimated 29.51165 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Boston to Florence?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 15728 reviews.
Which bus company has the best Wi-Fi from Boston to Florence?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Boston to Florence?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Boston to Florence?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

09-18

$137

09-19

$150

Today

$150

09-21

$139

09-22

$148

09-23

$168

09-24

$173

09-25

$214

The cheapest trip from Boston, MA, US to Florence, SC, US was searched and found on Sep 18, 2026 with a price of $137

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Florence, SC, US, as early as possible.

You can expect to pay from $137 to $237 for a bus ticket from Boston, MA, US to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $139 which is on 2026-09-21.