Bus from Boston, MA, US to Florence, SC, US: Tickets & Schedules

Previously seen trips

Next departures for Boston to Florence on June 14
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationPrice and booking link
Greyhound + FlixBus
Bus
Boston (South Station)
Florence, SC
FlixBus + Greyhound
Bus
Brookline
Florence, SC
FlixBus + Greyhound
Bus
Boston (South Station)
Florence, SC
FlixBus + Greyhound
Bus
151 Steel Pl, Cambridge
Bus station
FlixBus + Greyhound
Bus
Boston (South Station)
Bus station

Compare 2 ways to go from Boston to Florence

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Florence. The journey takes about 18 hours 10 minutes, and with fares starting at just $198, it presents an excellent value for a comfortable ride.

9train per day
18h 10mAverage Duration
1176 kmDistance
107kgCO₂ emissions
Average Price$143 - $445Average Duration1d 4h
30kg CO₂e
Average Price$198 - $1,045Average Duration18h 10m
107kg CO₂e

Frequently asked questions about travelling from Boston, MA, US to Florence, SC, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

  1. How much is the bus ticket from Boston to Florence?

    The cheapest bus tickets from Boston to Florence start from $143. The average price for this route is around $186. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

  2. How long is the bus ride from Boston to Florence?

    The average bus travel time from Boston to Florence is 1d 4h, covering a distance of 1181 km. The quickest bus can get you there in 18h 30m and is operated by FlixBus.

  3. Which bus companies service the Boston to Florence route?

    Several major bus companies operate on this route with 6 buses available per day, including services from FlixBus, Greyhound.

  4. What are the earliest and latest departure times for the bus from Boston to Florence?

    The earliest bus departs from Boston to Florence at 1:30am. And the latest bus departs at 10:00pm.

  5. What are the CO₂ emissions for the bus trip from Boston to Florence?

    A bus trip from Boston to Florence generates an estimated 29.51415 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

  6. What is the best bus company from Boston to Florence?

    According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 12791 reviews.

  7. Which bus company has the best Wi-Fi from Boston to Florence?

    Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.

  8. Which bus company has the best on-time performance from Boston to Florence?

    According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.

  9. Which bus company has the cleanest buses from Boston to Florence?

    According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-12
$163
06-13
$150
Today
$145
06-15
$128
06-16
$140
06-17
$178
06-18
$193
06-19
$188
busbud logoThe cheapest trip from Boston, MA, US to Florence, SC, US was searched and found on Jun 15, 2026 with a price of $128

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Florence, SC, US, as early as possible.

You can expect to pay from $128 to $300 for a bus ticket from Boston, MA, US to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $128 which is on 2026-06-15.

Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

What's the cheapest way to go from Boston, MA, US to Florence, SC, US?

busbud logoThe Bus is the cheapest travel choice for this destination

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