Bus Tickets from Boston, MA, US to Florence, SC, US
Next bus departures
Next departures for Boston to Florence on November 19
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FlixBus + Greyhound Lines, Inc.
Bus
Boston (South Station)
Florence, SC
CheapestFastest
FlixBus + Greyhound Lines, Inc.
Bus
Brookline
Florence, SC
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Last refresh of the prices: Yesterday at 7:18 AM EST.
Compare 2 ways to go from Boston to Florence
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach Florence. The journey takes about 18 hours and with fares starting at just $121, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Boston, MA, US to Florence, SC, US by bus
What is the travel distance from Boston to Florence?
The distance separating Boston and Florence is 729 miles (1176 km).
What are the departure and arrival stations when taking the bus from Boston to Florence?
The majority of buses traveling from Boston to Florence start their journey at Back Bay Station and wind up at Florence Bus Station. These are the most popular departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
What are the best sights and things to do in Florence?
Once in Florence, you can start exploring the city and discover its surroundings. The top sights and things to do are Galleria dell’Accademia, Museo Galileo - Institute and Museum of the History of Science, Museo degli Innocenti, Palazzo Vecchio and Galleria degli Uffizi.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/17
$88
11/18
$105
Today
$128
11/20
$125
11/21
$155
11/22
No data
11/23
No data
11/24
$175
The cheapest trip from Boston, MA, US to Florence, SC, US was searched and found on Nov 17, 2025 with a price of $88
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Florence, SC, US, as early as possible.
You can expect to pay from $88 to $195 for a bus ticket from Boston, MA, US to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $125 which is on 2025-11-20.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Boston, MA, US to Florence, SC, US?
The bus is the cheapest travel choice for this destination
The cheapest trip from Boston, MA, US to Florence, SC, US was searched and found on Nov 17, 2025 with a price of $88
The bus is the cheapest travel choice for this destination
