Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Columbus (E Mound St) | Gateway Station | Cheapest | ||||
| Bus | Columbus (E Mound St) | Gateway Station | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | 100 E Rich St | Gateway Station | No tags | ||||
 | Bus | 100 E Rich St | Gateway Station | No tags | ||||
| Bus | Columbus (E Mound St) | Gateway Station | No tags |
Last refresh of the prices: Today at 01:45 EST.
Get from Columbus to St. Louis
The journey takes about 11 hours 30 minutes, and with fares starting at just £40, it presents an excellent value for a comfortable ride.
Where are the popular stops in Columbus and St. Louis?
Stops in Columbus
- A
Columbus Bus Station
25 E Rich St, Columbus, OH 43205, USA
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Frequently asked questions about travelling by bus from Columbus, OH to St. Louis
What's the distance between Columbus and St. Louis by coach?
The distance between Columbus and St. Louis by coach is approximately 396 miles (638 km).
How can I travel from Columbus to St. Louis avoiding air travel?
You can choose the coach to travel this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Columbus, OH to St. Louis was searched and found on 1 Dec 2025 with a price of £43To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbus, OH to St. Louis as early as possible.
You can expect to pay from £43 to £153 for a bus ticket from Columbus, OH to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at £43, which is on 2025-12-01.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
