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- This trip is recommended because it is the: Cheapest + FastestDeparture time: 15 June atDeparture city: Des MoinesDeparture location: Des Moines (Subway)Arrival time: 15 June atDestination city: ChicagoDestination location: Downtown Greyhound StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration:
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Bus Des Moines to Chicago: Trip Overview
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Des Moines to Chicago Bus
With Busbud, comparing and booking tickets for a bus from Des Moines to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make sure you can find a bus service from Des Moines to Chicago from the most reliable bus companies operating this trip.
From cheap bus tickets to more luxurious buses travelling from Des Moines to Chicago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Des Moines and Chicago?
Frequently asked questions on the trip Des Moines - Chicago
How much does it cost to go to Chicago by bus?
Coach ticket prices from Des Moines to Chicago can start as low as US$48, though the average price for this trip is US$64. The actual price may differ based on factors like the time you plan to travel, the day of the week, and the coach service provider you select. To get accurate and up-to-date pricing information, check out all your options on our search tool.
How long is a coach from Des Moines to Chicago?
The coach journey between Des Moines and Chicago lasts about 8h 5m. The fastest coach journey typically takes 6h 10m. However, please keep in mind that your specific travel time may vary due to the prevailing traffic conditions along the route.
At what time is the first coach from Des Moines to Chicago?
The first coach from Des Moines to Chicago leaves at 05:30. Keep in mind that departure times might change on weekends and holidays.
What's the distance between Des Moines and Chicago by coach?
The journey from Des Moines to Chicago by coach covers an approximate distance of 308 miles (496 km).
What is the best way to go from Des Moines to Chicago without flying?
To travel from Des Moines to Chicago without flying, you can take the coaches. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.
Can I catch a night bus from Des Moines to Chicago?
Yes, you can find coaches leaving until 23:15 and arriving the next day. Remember to bring along some essentials like a snuggly blanket and a few treats for a comfortable trip.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Chicago was searched and found on 18 Jun 2025 with a price of US$44To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Chicago as early as possible.
You can expect to pay from US$44 to US$173 for a bus ticket from Des Moines to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$44, which is on 2025-06-18.
Usually Burlington Trailways will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Des Moines to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Des Moines to Chicago, get comfy and count the stars.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Des Moines to Chicago that are otherwise impossible to come by with a plane.
Make a music playlist for your bus ride from Des Moines to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
Top travelled bus routes
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Popular Buses Connecting Des Moines
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