Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus
| Indianapolis (W Vermont St) | Syracuse (Regional Transportation Center) | Cheapest | ||||
 | Bus
| Indianapolis Bus Station | Syracuse (Regional Transportation Center) | Fastest | ||||
| Bus
| Indianapolis Bus Station | Syracuse (Regional Transportation Center) | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus
| Indianapolis (W Vermont St) | Syracuse (Regional Transportation Center) | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus
| Indianapolis (W Vermont St) | Syracuse (Regional Transportation Center) | No tags |
Last refresh of the prices: Today at 15:58 EDT.
Compare 2 ways to travel from Indianapolis to Syracuse
Among the sustainable travel choices, the Bus stands out as a good way to reach Syracuse. The journey takes about 21 hours and with fares starting at just £70, it presents an excellent value for a comfortable ride.
Bus stations and stops in Indianapolis and Syracuse
Stops in Syracuse
- A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208 - C
Syracuse University
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210 - D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA - E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA - F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA
Compare companies
Frequently asked questions about travelling by bus from Indianapolis to Syracuse, US
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Indianapolis to Syracuse?
The cheapest coach tickets from Indianapolis to Syracuse start from £70. The average price for this route is around £86. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Indianapolis to Syracuse?
The average bus journey time from Indianapolis to Syracuse is 21h, covering a distance of 565 miles. The fastest bus can take you there in 19h 45m and is operated by Greyhound.
Which bus companies service the Indianapolis to Syracuse route?
What is the earliest and latest departure time for the bus from Indianapolis to Syracuse?
The earliest bus departs from Indianapolis to Syracuse at 00:15. And the latest bus departs at 23:25.
What are the CO₂ emissions for the bus trip from Indianapolis to Syracuse?
A bus journey from Indianapolis to Syracuse produces an estimated 22.747700000000002 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Indianapolis to Syracuse?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 6570 reviews.
Which company has the best Wi-Fi from Indianapolis to Syracuse?
Based on Busbud reviews, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company offers the most punctual service from Indianapolis to Syracuse?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Indianapolis to Syracuse?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Indianapolis to Syracuse, US was searched and found on 20 Oct 2026 with a price of £74To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Syracuse, US as early as possible.
You can expect to pay from £74 to £157 for a bus ticket from Indianapolis to Syracuse, US based on the last 2 days. You can expect to find the cheapest price for the trip at £74, which is on 2026-10-20.
What's the cheapest way to go from Indianapolis to Syracuse, US?
The Bus is the cheapest travel choice for this destination
