Next available departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Indianapolis Bus Station | Syracuse (Regional Transportation Center) | Cheapest | |||||
FlixBus + Greyhound Lines, Inc. | Downtown Transit Center | Syracuse (Regional Transportation Center) | Fastest | |||||
 | Greyhound Amtrak Station | SYR Airport | No tags | |||||
| Indianapolis Bus Station | Syracuse (Regional Transportation Center) | No tags | |||||
FlixBus + Greyhound Lines, Inc. | Downtown Transit Center | Syracuse (Regional Transportation Center) | No tags |
Last refresh of the prices: Yesterday at 12:51 PM EDT.
Compare 2 ways to go from Indianapolis to Syracuse
Among the sustainable travel choices, the Bus stands out as a good way to reach Syracuse. The journey takes about 20 hours 10 minutes, and with fares starting at just $130, it presents an excellent value for a comfortable ride.
Where are the popular stops in Indianapolis and Syracuse?
Stops in Syracuse
- A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208 - CBus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
- D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA - E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA - F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA
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Frequently asked questions about travelling from Indianapolis to Syracuse, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Indianapolis to Syracuse?
The cheapest bus tickets from Indianapolis to Syracuse start from $130. The average price for this route is around $159. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Indianapolis to Syracuse?
The average bus travel time from Indianapolis to Syracuse is 20h 10m, covering a distance of 910 km. The quickest bus can get you there in 19h 45m and is operated by Greyhound.
Which bus companies service the Indianapolis to Syracuse route?
What are the earliest and latest departure times for the bus from Indianapolis to Syracuse?
The earliest bus departs from Indianapolis to Syracuse at 12:15am. And the latest bus departs at 11:30pm.
What are the CO₂ emissions for the bus trip from Indianapolis to Syracuse?
A bus trip from Indianapolis to Syracuse generates an estimated 22.743575 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Indianapolis to Syracuse?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5809 reviews.
Which bus company has the best Wi-Fi from Indianapolis to Syracuse?
Based on Busbud reviews, the bus company Amtrak has the highest Wi-Fi rating with a score of 3.6.
Which bus company has the best on-time performance from Indianapolis to Syracuse?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Indianapolis to Syracuse?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Indianapolis to Syracuse, US was searched and found on Jun 9, 2026 with a price of $174To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Syracuse, US, as early as possible.
You can expect to pay from $174 to $1,983 for a bus ticket from Indianapolis to Syracuse, US based on the last 2 days. You can expect to find the cheapest price for the trip at $174 which is on 2026-06-09.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Indianapolis to Syracuse, US?
The Bus is the cheapest travel choice for this destination
