Next bus departures

Next departures for Indianapolis to Syracuse on October 18
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus Wifi Toilet Power outlets	8:10pm	Indianapolis Bus Station	1d	8:25pm	Syracuse (Regional Transportation Center)	Cheapest
	Bus Wifi Toilet Power outlets	3:35pm	Indianapolis Bus Station	19h 45m	11:20am	Syracuse (Regional Transportation Center)	Fastest
FlixBus + Greyhound Lines, Inc.	Bus Wifi Toilet Power outlets	1:30pm	Indianapolis (W Vermont St)	21h 50m	11:20am	Syracuse (Regional Transportation Center)	No tags
FlixBus + Greyhound Lines, Inc.	Bus Wifi Toilet Power outlets	11:25pm	Indianapolis (W Vermont St)	21h	8:25pm	Syracuse (Regional Transportation Center)	No tags

Last refresh of the prices: Yesterday at 3:58 PM EDT.

Compare 2 ways to go from Indianapolis to Syracuse

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Syracuse. The journey takes about 21 hours and with fares starting at just $91, it presents an excellent value for a comfortable ride.

6bus per day

21hAverage Duration

565 milesDistance

23kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$91 - $229	Average Duration21h	CO₂ emissions 23kg CO₂e
Train	Average Price$183 - $1,201	Average Duration1d 5h	CO₂ emissions 83kg CO₂e

Bus stations and stops in Indianapolis and Syracuse

Stops in Indianapolis

A
Greyhound Amtrak Station
350 S Illinois St, Indianapolis, IN 46225
Visit page

Stops in Syracuse

A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208
B
Syracuse Airport
Visit page
C
Syracuse University
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
Visit page
D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA
E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA
F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA

Compare companies

Greyhound

3.5/588,240 reviews

Staff3.6

Timeliness3.0

Cleanliness3.4

Wifi2.5

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

Amtrak

4.1/56,575 reviews

Staff4.7

Timeliness3.8

Cleanliness4.5

Wifi3.6

FlixBus

3.5/516,291 reviews

Staff4.2

Timeliness4.0

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies:FlixBus, Greyhound, Tufesa, Chihuahuenses, Adirondack Trailways, Valley Transit, Wanda Coach

Frequently asked questions about traveling from Indianapolis to Syracuse, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Indianapolis to Syracuse?
The cheapest bus tickets from Indianapolis to Syracuse start from $91. The average price for this route is around $112. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Indianapolis to Syracuse?
The average bus trip duration from Indianapolis to Syracuse is 21h, covering a distance of 565 miles (910 km). The quickest bus can get you there in 19h 45m and is operated by Greyhound.
Which bus companies service the Indianapolis to Syracuse route?
Several major bus companies operate on this route with 6 buses available per day, including services from Greyhound, Amtrak, FlixBus.
What is the earliest and latest departure time for the bus from Indianapolis to Syracuse?
The earliest bus departs from Indianapolis to Syracuse at 12:15am. And the latest bus departs at 11:25pm.
What are the CO₂ emissions for the bus trip from Indianapolis to Syracuse?
A bus trip from Indianapolis to Syracuse generates an estimated 22.747700000000002 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Indianapolis to Syracuse?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 6551 reviews.
Which bus company has the best Wi-Fi from Indianapolis to Syracuse?
Based on reviews on Busbud, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company has the most timely service from Indianapolis to Syracuse?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Indianapolis to Syracuse?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

10/16

$101

10/17

$113

Today

$161

10/19

$98

10/20

$96

10/21

No data

10/22

No data

10/23

$92

The cheapest trip from Indianapolis to Syracuse, US was searched and found on Oct 23, 2026 with a price of $92

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Syracuse, US, as early as possible.

You can expect to pay from $92 to $204 for a bus ticket from Indianapolis to Syracuse, US based on the last 2 days. You can expect to find the cheapest price for the trip at $92 which is on 2026-10-23.