Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Milwaukee Bus Station, St. Paul & N6th road. | Knoxville Bus Station | Cheapest | ||||
| Bus | Milwaukee Bus Station, St. Paul & N6th road. | Knoxville Bus Station | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Milwaukee Bus Station, St. Paul & N6th road. | Knoxville Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Milwaukee Mitchell MKE Airport | Knoxville Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Milwaukee Mitchell MKE Airport | Knoxville Bus Station | No tags |
Last refresh of the prices: Yesterday at 15:03 CST.
Get from Milwaukee to Knoxville
The journey takes about 22 hours 40 minutes, and with fares starting at just £111, it presents an excellent value for a comfortable ride.
Where are the popular stops in Milwaukee and Knoxville?
Stops in Milwaukee
- B433 W St Paul Ave, Milwaukee, WI 53203, USA
- C
S Cesar Chavez
1016 S Cesar E Chavez Dr, Milwaukee, WI 53204, USA
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Based on 87518 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Greyhound ticket prices on this trip start at £121
Frequently asked questions about travelling by bus from Milwaukee to Knoxville, TN
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Milwaukee to Knoxville?
The cheapest coach tickets from Milwaukee to Knoxville start from £111. The average price for this route is around £117. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Milwaukee to Knoxville?
The average bus journey time from Milwaukee to Knoxville is 22h 40m, covering a distance of 531 miles. The fastest bus can take you there in 18h 15m and is operated by Greyhound.
Which bus companies service the Milwaukee to Knoxville route?
Several major bus companies operate on this route with 6 buses available per day.
What is the earliest and latest departure time for the bus from Milwaukee to Knoxville?
The earliest bus departs from Milwaukee to Knoxville at 03:25. And the latest bus departs at 19:35.
What are the CO₂ emissions for the bus trip from Milwaukee to Knoxville?
A bus journey from Milwaukee to Knoxville produces an estimated 21 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Milwaukee to Knoxville, TN was searched and found on 31 Jan 2026 with a price of £169To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Milwaukee to Knoxville, TN as early as possible.
You can expect to pay from £169 to £185 for a bus ticket from Milwaukee to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at £169, which is on 2026-01-31.
