Previously seen journeys
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound + FlixBus | Bus | UCSD Health La Jolla Station | Mesa Bus Stop | No tags | ||||
FlixBus + Greyhound | Bus | San Diego (Old Town-FlixBus) | Mesa Bus Stop | No tags | ||||
FlixBus + Greyhound | Bus | UCSD Health La Jolla Station | Mesa Bus Stop | No tags | ||||
 | Bus | Greyhound Bus Stop | Mesa Bus Stop | No tags | ||||
| Bus | Greyhound Bus Stop | Mesa Bus Stop | No tags |
Get from San Diego to Mesa
The journey takes about 12 hours 35 minutes, and with fares starting at just £44, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Diego and Mesa?
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Stops in Mesa
- A
Mesa Bus Station
1423 S Country Club , Mesa, AZ 85210, USA
Compare bus companies
Frequently asked questions about travelling by bus from San Diego, CA, US to Mesa
How far is Mesa from San Diego by coach?
The distance between San Diego and Mesa by coach is approximately 312 miles (502 km).
What is the best way to go from San Diego to Mesa without flying?
You can choose the coach to travel this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You also have the option of utilising carpooling services.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to Mesa was searched and found on 26 Nov 2025 with a price of £60To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Mesa as early as possible.
You can expect to pay from £60 to £60 for a bus ticket from San Diego, CA, US to Mesa based on the last 2 days. You can expect to find the cheapest price for the trip at £60, which is on 2025-11-26.
