Find coaches from San Francisco, US to Santa Ana, US

Next departures

Next departures from San Francisco to Santa Ana on 14 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
San Francisco Bus Station
Anaheim Regional Transportation Intermodal CenterCheapest
Greyhound Lines, Inc.
San Francisco Bus Station
Anaheim Regional Transportation Intermodal CenterFastest
FlixBus + Greyhound Lines, Inc.
409 Townsend St, SF
Anaheim Regional Transportation Intermodal CenterNo tags
Greyhound Lines, Inc.
San Francisco Bus Station
Santa Ana Bus StationNo tags
FlixBus + Greyhound Lines, Inc.
409 Townsend St, SF
Santa Ana Bus StationNo tags

Last refresh of the prices: Yesterday at 09:57 PDT.

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Bus San Francisco, US to Santa Ana, US: Trip Overview

Average ticket priceUS$77
Average bus trip duration11h 20m
Number of daily buses11
Earliest bus departure06:30
Distance373 miles
Latest bus departure23:25

San Francisco to Santa Ana Bus

With Busbud, comparing and booking tickets for a bus from San Francisco to Santa Ana is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from San Francisco to Santa Ana will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Santa Ana from San Francisco, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip San Francisco, US - Santa Ana, US

  1. How far is Santa Ana from San Francisco by coach?

    The journey from San Francisco to Santa Ana by coach covers an approximate distance of 378 miles (609 km).

  2. What is the best way to go from San Francisco to Santa Ana without flying?

    To travel from San Francisco to Santa Ana without flying, you can take the coaches. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11/10
US$168
12/10
US$151
Today
US$157
14/10
US$93
15/10
US$86
16/10
US$89
17/10
No data
18/10
No data
busbud logoThe cheapest trip from San Francisco, US to Santa Ana, US was searched and found on 15 Oct 2025 with a price of US$86

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Francisco, US to Santa Ana, US as early as possible.

You can expect to pay from US$86 to US$168 for a bus ticket from San Francisco, US to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$86, which is on 2025-10-15.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from San Francisco to Santa Ana.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from San Francisco to Santa Ana, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from San Francisco to Santa Ana.

Tune out to the fine sounds of your best music playlist on your bus trip from San Francisco to Santa Ana while indulging in miles on end of beautiful scenic views.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to San Francisco, US by bus?

Bus from Santa Ana, US to San Francisco, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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