Find coaches from Des Moines to Indianapolis

Next departures

Next departures from Des Moines to Indianapolis on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Des Moines
Indianapolis Bus StationCheapest
Jefferson Lines
Des Moines
IndianapolisFastest
Greyhound Lines, Inc.
Des Moines
Indianapolis Bus StationNo tags
Greyhound Lines, Inc. + FlixBus
Des Moines
Downtown Transit CenterNo tags
Greyhound Lines, Inc. + FlixBus
Des Moines
Downtown Transit CenterNo tags

Last refresh of the prices: Last Monday at 8:55 PM CDT.

Accepted payments

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Get from Des Moines to Indianapolis

busbud logoThis route is served by bus only

The journey takes about 13 hours, and with fares starting at just US$55, it presents an excellent value for a comfortable ride.

4bus per day
13hAverage duration
660 kmDistance
16kgCO₂ emissions

Bus Des Moines to Indianapolis: Trip Overview

Average ticket priceUS$93
Average bus trip duration13h
Number of daily buses4
Earliest bus departure05:30
Distance660 km
Latest bus departure09:30

Des Moines to Indianapolis Bus

Busbud helps you find a bus from Des Moines to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Des Moines to Indianapolis.

From cheap bus tickets to more luxurious buses travelling from Des Moines to Indianapolis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Des Moines - Indianapolis

  1. How much does a bus ticket from Des Moines to Indianapolis cost?

    The bus ticket price from Des Moines to Indianapolis starts at US$55. The best way to find cheap bus tickets from Des Moines to Indianapolis is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Des Moines to Indianapolis?

    The average travel time between Des Moines and Indianapolis is around 13h, although the fastest bus will take about 10h 20m. This is the time it takes to travel the 661 km that separates the two cities.

  3. How many daily bus connections are there between Des Moines and Indianapolis?

    The number of buses from Des Moines to Indianapolis can differ depending on the day of the week. On average, there are 4 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Des Moines to Indianapolis by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Des Moines to Indianapolis?

    When taking the bus from Des Moines to Indianapolis, you can travel comfortably and safely with Greyhound, Jefferson Lines, Burlington Trailways.

  5. What are the departure and arrival stations when taking the bus from Des Moines to Indianapolis?

    Buses travelling between Des Moines and Indianapolis leave from Jefferson/Trailways Depot or 1514 East Grand Ave and arrive at Greyhound Amtrak Station.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$73
29/10
No data
Today
US$64
31/10
US$82
01/11
No data
02/11
No data
03/11
No data
04/11
No data
busbud logoThe cheapest trip from Des Moines to Indianapolis was searched and found on 30 Oct 2025 with a price of US$64

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Indianapolis as early as possible.

You can expect to pay from US$64 to US$106 for a bus ticket from Des Moines to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at US$82, which is on 2025-10-31.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Des Moines and Indianapolis!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Des Moines to Indianapolis.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Des Moines to Indianapolis that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Des Moines to Indianapolis.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Des Moines by bus?

Bus from Indianapolis to Des Moines

Why choose Busbud?

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