Bus Tickets from Des Moines to Indianapolis

Find affordable bus tickets from Des Moines to Indianapolis with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayJul 24
TomorrowJul 25
from US$98
SatJul 26
SunJul 27
MonJul 28
TueJul 29
WedJul 30
ThuJul 31

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: July 25 at
    Departure city: Des Moines
    Departure location: Des Moines (Subway)
    Arrival time: July 25 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 25 at
    Departure city: Des Moines
    Departure location: Des Moines (Subway)
    Arrival time: July 25 at
    Destination city: Indianapolis
    Destination location: Downtown Transit Center
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

Last refresh of the prices: Last Friday at 12:02 PM CDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Des Moines to Indianapolis: Trip Overview

Average Ticket PriceUS$105
Average Bus Trip Duration12h 20m
Number of daily buses2
Earliest bus departure5:30am
Distance659 km
Latest bus departure8:15am

Des Moines to Indianapolis Bus

Busbud helps you find a bus from Des Moines to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Des Moines to Indianapolis.

From cheap bus tickets to more luxurious buses travelling from Des Moines to Indianapolis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Des Moines - Indianapolis

  1. What is the travel distance from Des Moines to Indianapolis?

    The distance covered from Des Moines to Indianapolis is 661 km (410 miles).

  2. What are the departure and arrival locations for buses traveling from Des Moines to Indianapolis?

    Buses traveling this route start their trip at Jefferson/Trailways Depot, in Des Moines, and end it at Greyhound Amtrak Station, in Indianapolis.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07-22
US$78
07-23
US$85
Today
US$88
07-25
US$90
07-26
No data
07-27
No data
07-28
No data
07-29
US$80
busbud logoThe cheapest trip from Des Moines to Indianapolis was searched and found on Jul 22, 2025 with a price of US$78

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Indianapolis, as early as possible.

You can expect to pay from US$78 to US$90 for a bus ticket from Des Moines to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at US$80 which is on 2025-07-29.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Des Moines and Indianapolis!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Des Moines to Indianapolis.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Des Moines to Indianapolis that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Des Moines to Indianapolis.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Des Moines by bus?

Bus from Des Moines to Indianapolis

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

People from around the world trust Busbud

‌

Popular Buses Connecting Des Moines

Buses Leaving from Des Moines

Buses Going to Des Moines

Popular Buses Connecting Indianapolis

Buses Leaving from Indianapolis

Buses Going to Indianapolis