Find coaches from Greenville, SC to Indianapolis

Next departures

Next departures from Greenville to Indianapolis on 1 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
    		1116 Woodruff Rd
    		Indianapolis Bus StationCheapest
    FlixBus + Greyhound Lines, Inc.
      		1116 Woodruff Rd
      		Indianapolis Bus StationFastest
      Greyhound Lines, Inc.
        		1116 Woodruff Rd
        		Indianapolis Bus StationNo tags
        FlixBus + Greyhound Lines, Inc.
          		1116 Woodruff Rd
          		Indianapolis Bus StationNo tags
          FlixBus
            		1116 Woodruff Rd
            		Downtown Transit CenterNo tags

            Last refresh of the prices: Yesterday at 5:33 PM EDT.

            Accepted payments

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            • China Union Pay
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            • JCB payment
            • Klarna (Pay over time)
            • Google Pay

            Compare 2 ways to travel from Greenville to Indianapolis

            We recommend taking the bus

            Among the sustainable travel choices, the bus stands out as a good way to reach Indianapolis. The journey takes about 17 hours 40 minutes and with fares starting at just US$81, it presents an excellent value for a comfortable ride.

            6bus per day
            17h 40mAverage duration
            646 kmDistance
            16kgCO₂ emissions
            Bus
            		Average priceUS$81 - US$184Average duration17h 40m
            16kg CO₂e
            Train
            		Average priceUS$176 - US$1 323Average duration1d 2h
            58kg CO₂e

            Bus Greenville, SC to Indianapolis: Trip Overview

            Average ticket priceUS$121
            Average bus trip duration17h 40m
            Number of daily buses6
            Earliest bus departure13:25
            Distance646 km
            Latest bus departure22:00

            Greenville to Indianapolis Bus

            Busbud helps you find a bus from Greenville to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

            We make it our job to connect you with the most dependable bus companies that cover bus service from Greenville to Indianapolis.

            Discover how much the bus trip from Greenville to Indianapolis will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

            Frequently asked questions on the trip Greenville, SC - Indianapolis

            1. How much does a bus ticket from Greenville to Indianapolis cost?

              The bus ticket price from Greenville to Indianapolis starts at US$81. The best way to find cheap bus tickets from Greenville to Indianapolis is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

            2. How long is the bus ride from Greenville to Indianapolis?

              The average travel time between Greenville and Indianapolis is around 17h 40m, although the fastest bus will take about 15h 20m. This is the time it takes to travel the 641 km that separates the two cities.

            3. How many daily bus connections are there between Greenville and Indianapolis?

              The number of buses from Greenville to Indianapolis can differ depending on the day of the week. On average, there are 6 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Greenville to Indianapolis by comparing and selecting the bus that fits your travel style and budget on Busbud.

            4. Which bus companies travel from Greenville to Indianapolis?

              When taking the bus from Greenville to Indianapolis, you can travel comfortably and safely with FlixBus, Greyhound.

            5. What are the departure and arrival stations when taking the bus from Greenville to Indianapolis?

              Buses travelling between Greenville and Indianapolis leave from Guadalajara Supermarket Bus Stop or Greenville Bus Station and arrive at Greyhound Amtrak Station.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            30/10
            US$156
            31/10
            US$79
            Today
            US$125
            02/11
            US$94
            03/11
            No data
            04/11
            No data
            05/11
            No data
            06/11
            No data
            busbud logoThe cheapest trip from Greenville, SC to Indianapolis was searched and found on 31 Oct 2025 with a price of US$79

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Indianapolis as early as possible.

            You can expect to pay from US$79 to US$156 for a bus ticket from Greenville, SC to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at US$94, which is on 2025-11-02.

            About Bus Travel

            Bus Travel Tips

            Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Greenville and Indianapolis!

            From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Greenville to Indianapolis.

            Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Greenville to Indianapolis will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

            Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Greenville to Indianapolis.

            Did you know?

            Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

            Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

            It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

            What's the cheapest way to go from Greenville, SC to Indianapolis?

            busbud logoThe bus is the cheapest travel choice for this destination

            Will you be returning to Greenville, SC by bus?

            Bus from Indianapolis to Greenville, SC

            You can also go to Indianapolis by train

            Train from Greenville, SC to Indianapolis

            Why choose Busbud?

            The Best Way To Book Bus and Train Tickets

            Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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