Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | 1116 Woodruff Rd | Indianapolis Bus Station | Cheapest | |||||
FlixBus + Greyhound Lines, Inc. | 1116 Woodruff Rd | Indianapolis Bus Station | Fastest | |||||
 | 1116 Woodruff Rd | Indianapolis Bus Station | No tags | |||||
FlixBus + Greyhound Lines, Inc. | 1116 Woodruff Rd | Indianapolis Bus Station | No tags | |||||
 | 1116 Woodruff Rd | Downtown Transit Center | No tags |
Last refresh of the prices: Yesterday at 5:33 PM EDT.
Accepted payments
Compare 2 ways to go from Greenville to Indianapolis
Among the sustainable travel choices, the bus stands out as the good way to reach Indianapolis. The journey takes about 17 hours 40 minutes and with fares starting at just $81, it presents an excellent value for a comfortable ride.
Bus Greenville, SC to Indianapolis: Trip Overview
Compare bus companies
Greenville to Indianapolis Bus
Busbud helps you find a bus from Greenville to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make it our job to connect you with the most dependable bus companies that cover bus service from Greenville to Indianapolis.
Discover how much the bus trip from Greenville to Indianapolis will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Greenville and Indianapolis?
Frequently asked questions for your trip Greenville, SC - Indianapolis
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Greenville, SC to Indianapolis was searched and found on Oct 31, 2025 with a price of $79To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Indianapolis, as early as possible.
You can expect to pay from $79 to $156 for a bus ticket from Greenville, SC to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $94 which is on 2025-11-02.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Greenville and Indianapolis!
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Greenville to Indianapolis.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Greenville to Indianapolis will emit less CO2 than a car or an airplane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Greenville to Indianapolis.
Did you know?
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
What's the cheapest way to go from Greenville, SC to Indianapolis?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
Why choose Busbud?
The Best Way To Book Bus and Train Tickets
Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
People from around the world trust Busbud
Popular Buses Connecting Greenville
Buses Leaving from Greenville
- Bus from Greenville to Spartanburg
- Bus Greenville - Charleston
- Greenville - Charleston
- Bus from Greenville to Greensboro
- Bus Greenville - Miami
- Greenville - Chicago
- Bus from Greenville to Charlotte
- Bus Greenville - Atlanta
- Greenville - New York City
- Bus from Greenville to Knoxville
- Bus Greenville - Orlando
- Greenville - Tarboro
- Bus from Greenville to Macon
- Bus Greenville - Dallas
- Greenville - Anderson
Buses Going to Greenville
- Bus from Atlanta to Greenville
- Bus Burlington - Greenville
- Nashville - Greenville
- Bus from Knoxville to Greenville
- Bus Savannah - Greenville
- Orlando - Greenville
- Bus from Charlotte to Greenville
- Bus Charleston - Greenville
- Anderson - Greenville
- Bus from New York City to Greenville
- Bus Asheville - Greenville
- Miami - Greenville
- Bus from Spartanburg to Greenville
- Bus Myrtle Beach - Greenville
- Raleigh - Greenville
Popular Buses Connecting Indianapolis
Buses Leaving from Indianapolis
- Bus from Indianapolis to Muncie
- Bus Indianapolis - Nashville
- Indianapolis - Chicago
- Bus from Indianapolis to Bloomington
- Bus Indianapolis - Bloomington
- Indianapolis - Temple
- Bus from Indianapolis to New York City
- Bus Indianapolis - Atlanta
- Indianapolis - Columbus
- Bus from Indianapolis to Cincinnati
- Bus Indianapolis - Miami
- Indianapolis - Boston
- Bus from Indianapolis to South Bend
- Bus Indianapolis - Orlando
- Indianapolis - Detroit
Buses Going to Indianapolis
- Bus from South Bend to Indianapolis
- Bus Bloomington - Indianapolis
- Bloomington - Indianapolis
- Bus from Merrillville to Indianapolis
- Bus Terre Haute - Indianapolis
- Greenfield - Indianapolis
- Bus from Chicago to Indianapolis
- Bus New York City - Indianapolis
- Columbus - Indianapolis
- Bus from Houston to Indianapolis
- Bus Detroit - Indianapolis
- Dallas - Indianapolis
- Bus from Cincinnati to Indianapolis
- Bus Atlanta - Indianapolis
- Nashville - Indianapolis
Popular routes in this country
- Bus from Fort Lauderdale to Orlando
- Bus Dallas - Houston
- Albany - New York City
- Bus from Las Vegas to Los Angeles
- Bus Tampa - Miami
- Austin - Dallas
- Bus from Dallas to Austin
- Bus Seattle - Leavenworth
- Miami - Tampa
- Bus from Austin to Houston
- Bus Houston - San Antonio
- Houston - Austin
- Bus from San Antonio to Houston
- Bus Atlanta - Orlando
- Dallas - San Antonio