How much is the bus ticket from Greenville to Indianapolis?

The cheapest bus tickets from Greenville to Indianapolis start from TRY 3,804. The average price for this route is around TRY 4,770. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Greenville to Indianapolis?

The average bus trip duration from Greenville to Indianapolis is 18h 45m, covering a distance of 401 miles (646 km). The quickest bus can get you there in 15h 45m and is operated by Greyhound .

Which bus companies service the Greenville to Indianapolis route?

Several major bus companies operate on this route with 6 buses available per day, including services from Greyhound , FlixBus .

What is the earliest and latest departure time for the bus from Greenville to Indianapolis?

The earliest bus departs from Greenville to Indianapolis at 1:20pm. And the latest bus departs at 10:00pm.

What are the CO₂ emissions for the bus trip from Greenville to Indianapolis?

A bus trip from Greenville to Indianapolis generates an estimated 16.1412 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Greenville to Indianapolis?

According to Busbud customers, the highest-rated bus company on this route is Greyhound , with an average rating of 3.5 out of 5 stars based on 87532 reviews.

Which bus company has the best Wi-Fi from Greenville to Indianapolis?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Greenville to Indianapolis?

According to Busbud traveler reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 4.0 out of 5 stars.

Which bus company has the cleanest buses from Greenville to Indianapolis?

According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Greenville to Indianapolis from TRY 3,612 | Refundable Tickets

Previously seen trips

Next departures for Greenville to Indianapolis on April 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound + FlixBus	Bus	3:30pm	1116 Woodruff Rd	16h 55m	8:25am	Downtown Transit Center	No tags
	Bus	6:05pm	1116 Woodruff Rd	15h 50m	9:55am	Indianapolis Bus Station	No tags
FlixBus + Greyhound	Bus	7:45pm	1116 Woodruff Rd	16h 20m	12:05pm	Indianapolis Bus Station	No tags
FlixBus + Greyhound	Bus	10:00pm	1116 Woodruff Rd	23h 25m	9:25pm	Downtown Transit Center	No tags
Greyhound + FlixBus	Bus	10:00pm	1116 Woodruff Rd	20h 40m	6:40pm	Indianapolis Bus Station	No tags

Compare 2 ways to go from Greenville to Indianapolis

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Indianapolis. The journey takes about 18 hours 45 minutes and with fares starting at just TRY 3,804, it presents an excellent value for a comfortable ride.

6bus per day

18h 45mAverage Duration

401 milesDistance

16kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average PriceTRY 3,804 - TRY 9,855	Average Duration18h 45m	CO₂ emissions 16kg CO₂e
Train	Average PriceTRY 7,391 - TRY 15,345	Average Duration1d 3h	CO₂ emissions 58kg CO₂e

Where are the popular stops in Greenville and Indianapolis?

Stops in Greenville

A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611
B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607

Stops in Indianapolis

A
Greyhound Amtrak Station
350 S Illinois St, Indianapolis, IN 46225
Visit page

Compare bus companies

Greyhound

3.5/587,542 reviews

Staff3.6

Timeliness2.9

Cleanliness3.4

Wifi2.5

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/512,510 reviews

Staff4.2

Timeliness4.0

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies:FlixBus, Greyhound, Futura, Elite, Chihuahuenses, Tufesa, Los Limousines

Frequently asked questions about traveling from Greenville, SC to Indianapolis by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Greenville to Indianapolis?
The cheapest bus tickets from Greenville to Indianapolis start from TRY 3,804. The average price for this route is around TRY 4,770. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Greenville to Indianapolis?
The average bus trip duration from Greenville to Indianapolis is 18h 45m, covering a distance of 401 miles (646 km). The quickest bus can get you there in 15h 45m and is operated by Greyhound.
Which bus companies service the Greenville to Indianapolis route?
Several major bus companies operate on this route with 6 buses available per day, including services from Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from Greenville to Indianapolis?
The earliest bus departs from Greenville to Indianapolis at 1:20pm. And the latest bus departs at 10:00pm.
What are the CO₂ emissions for the bus trip from Greenville to Indianapolis?
A bus trip from Greenville to Indianapolis generates an estimated 16.1412 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Greenville to Indianapolis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87532 reviews.
Which bus company has the best Wi-Fi from Greenville to Indianapolis?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Greenville to Indianapolis?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Greenville to Indianapolis?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

04/19

TRY 3,980

04/20

TRY 8,237

Today

TRY 3,980

04/22

TRY 3,980

04/23

TRY 3,842

04/24

No data

04/25

TRY 4,210

04/26

TRY 4,210

The cheapest trip from Greenville, SC to Indianapolis was searched and found on Apr 23, 2026 with a price of TRY 3,842

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Indianapolis, as early as possible.

You can expect to pay from TRY 3,842 to TRY 8,237 for a bus ticket from Greenville, SC to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at TRY 3,842 which is on 2026-04-23.