Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound + FlixBus | Bus | 1116 Woodruff Rd | Indianapolis Bus Station | No tags | ||||
 | Bus | 1116 Woodruff Rd | Downtown Transit Center | No tags | ||||
Greyhound + FlixBus | Bus | 1116 Woodruff Rd | Indianapolis Bus Station | No tags | ||||
 | Bus | 1116 Woodruff Rd | Indianapolis Bus Station | No tags | ||||
FlixBus + Greyhound | Bus | 1116 Woodruff Rd | Downtown Transit Center | No tags |
Compare 2 ways to go from Greenville to Indianapolis
Among the sustainable travel choices, the Bus stands out as a good way to reach Indianapolis. The journey takes about 17 hours 40 minutes, and with fares starting at just $123, it presents an excellent value for a comfortable ride.
Where are the popular stops in Greenville and Indianapolis?
Stops in Greenville
Stops in Indianapolis
- A350 S Illinois St, Indianapolis, IN 46225
Compare bus companies
Frequently asked questions about travelling from Greenville, SC to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Greenville to Indianapolis?
The cheapest bus tickets from Greenville to Indianapolis start from $123. The average price for this route is around $182. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Greenville to Indianapolis?
The average bus travel time from Greenville to Indianapolis is 17h 40m, covering a distance of 646 km. The quickest bus can get you there in 16h 10m and is operated by Greyhound.
Which bus companies service the Greenville to Indianapolis route?
What are the earliest and latest departure times for the bus from Greenville to Indianapolis?
The earliest bus departs from Greenville to Indianapolis at 1:20pm. And the latest bus departs at 10:00pm.
What are the CO₂ emissions for the bus trip from Greenville to Indianapolis?
A bus trip from Greenville to Indianapolis generates an estimated 16 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Greenville to Indianapolis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87500 reviews.
Which bus company has the best Wi-Fi from Greenville to Indianapolis?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Greenville to Indianapolis?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Greenville to Indianapolis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Greenville, SC to Indianapolis was searched and found on Jan 21, 2026 with a price of $127To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Indianapolis, as early as possible.
You can expect to pay from $127 to $217 for a bus ticket from Greenville, SC to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $127 which is on 2026-01-21.
What's the cheapest way to go from Greenville, SC to Indianapolis?
The Bus is the cheapest travel choice for this destination
