Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Jacksonville Bus Station | Florence, SC | Cheapest | ||||
| Bus | Jacksonville Bus Station | Bus station | Fastest |
Last refresh of the prices: Today at 3:47 PM EDT.
Compare 2 ways to travel from Jacksonville to Florence
Among the sustainable travel choices, the Bus stands out as a good way to reach Florence. The journey takes about 5 hours 10 minutes and with fares starting at just R 837, it presents an excellent value for a comfortable ride.
Where are the popular stops in Jacksonville and Florence?
Stops in Jacksonville
- A3570 Clifford Ln, Jacksonville, FL 32209, USA
- B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA - C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207 - D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Based on 12326 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained about the Wi-Fi. FlixBus ticket prices on this trip start at R 837
Frequently asked questions about travelling from Jacksonville, FL to Florence, SC, US by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Jacksonville to Florence?
The cheapest bus tickets from Jacksonville to Florence start at R 837. The average price for this route is around R 993. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Jacksonville to Florence?
The average bus journey time from Jacksonville to Florence is 5h 10m, covering a distance of 465 km. The fastest bus gets you there in 5h 10m and is operated by FlixBus.
Which bus companies service the Jacksonville to Florence route?
Several major bus companies operate on this route with 1 buses available per day.
What is the earliest and latest departure time for the bus from Jacksonville to Florence?
The earliest bus departs from Jacksonville to Florence at 08:15. And the latest bus departs at 18:30.
What are the CO₂ emissions for the bus trip from Jacksonville to Florence?
A bus trip from Jacksonville to Florence produces an estimated 12 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Jacksonville, FL to Florence, SC, US was searched and found on 13 Mar 2026 with a price of R 869To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville, FL to Florence, SC, US as early as possible.
You can expect to pay from R 869 to R 2 015 for a bus ticket from Jacksonville, FL to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 008, which is on 2026-03-16.
What's the cheapest way to go from Jacksonville, FL to Florence, SC, US?
The Bus is the cheapest travel choice for this destination
