Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Jacksonville Bus Station | Florence, SC | CheapestFastest |
Last refresh of the prices: Today at 12:46 PM EDT.
Compare 2 ways to go from Jacksonville to Florence
Among the sustainable travel choices, the Bus stands out as a good way to reach Florence. The journey takes about 5 hours 35 minutes and with fares starting at just COP 159,538, it presents an excellent value for a comfortable ride.
Where are the popular stops in Jacksonville and Florence?
Stops in Jacksonville
- A
Jacksonville Amtrak Station
3570 Clifford Ln, Jacksonville, FL 32209, USA - B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA - C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207 - D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA
Stops in Florence
- A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA - B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Frequently asked questions about traveling from Jacksonville, FL to Florence, SC, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Jacksonville to Florence?
The cheapest bus tickets from Jacksonville to Florence start from COP 159,538. The average price for this route is around COP 187,188. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Jacksonville to Florence?
The average bus trip duration from Jacksonville to Florence is 5h 35m, covering a distance of 289 miles (466 km). The quickest bus can get you there in 5h 10m and is operated by FlixBus.
Which bus companies service the Jacksonville to Florence route?
What is the earliest and latest departure time for the bus from Jacksonville to Florence?
The earliest bus departs from Jacksonville to Florence at 8:15am. And the latest bus departs at 6:30pm.
What are the CO₂ emissions for the bus trip from Jacksonville to Florence?
A bus trip from Jacksonville to Florence generates an estimated 11.636025 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Jacksonville to Florence?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 12853 reviews.
Which bus company has the best Wi-Fi from Jacksonville to Florence?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Jacksonville to Florence?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Jacksonville to Florence?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Jacksonville, FL to Florence, SC, US was searched and found on Jun 30, 2026 with a price of COP 165,863To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville, FL to Florence, SC, US, as early as possible.
You can expect to pay from COP 165,863 to COP 514,938 for a bus ticket from Jacksonville, FL to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at COP 452,726 which is on 2026-07-03.
What's the cheapest way to go from Jacksonville, FL to Florence, SC, US?
The Bus is the cheapest travel choice for this destination
