Find coaches from Jacksonville, FL to Florence, SC, US

Previously seen journeys

Next departures from Jacksonville to Florence on 28 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
Jacksonville Bus Station
Bus stationNo tags
FlixBus
Jacksonville Bus Station
Florence, SCNo tags
Greyhound
Jacksonville Bus Station
Bus stationNo tags
FlixBus
Jacksonville Bus Station
Florence, SCNo tags
Greyhound
Jacksonville Bus Station
Bus stationNo tags

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Compare 2 ways to travel from Jacksonville to Florence

busbud logoWe recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 7 hours and with fares starting at just US$51, it presents an excellent value for a comfortable ride.

2bus per day
7hAverage duration
289 milesDistance
12kgCO₂ emissions
Bus
Average priceUS$51 - US$99Average duration7h
12kg CO₂e
Train
Average priceUS$52 - US$117Average duration6h 11m
42kg CO₂e

Bus Jacksonville, FL to Florence, SC, US: Trip Overview

Average ticket priceUS$68
Average bus trip duration7h
Number of daily buses2
Earliest bus departure08:45
Distance289 miles
Latest bus departure18:30

Jacksonville to Florence Bus

With Busbud, comparing and booking tickets for a bus from Jacksonville to Florence is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Jacksonville to Florence will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Florence from Jacksonville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Jacksonville, FL - Florence, SC, US

  1. How far is Florence from Jacksonville by coach?

    The distance between Jacksonville and Florence by coach is approximately 293 miles (472 km).

  2. What is the best way to go from Jacksonville to Florence without flying?

    You can choose the coach to travel this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
25/10
US$51
26/10
US$63
Today
US$63
28/10
No data
29/10
US$43
30/10
US$40
31/10
US$41
01/11
US$40
busbud logoThe cheapest trip from Jacksonville, FL to Florence, SC, US was searched and found on 30 Oct 2025 with a price of US$40

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville, FL to Florence, SC, US as early as possible.

You can expect to pay from US$40 to US$88 for a bus ticket from Jacksonville, FL to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$40, which is on 2025-10-30.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Jacksonville to Florence.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Jacksonville to Florence, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Jacksonville to Florence.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Jacksonville to Florence.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

What's the cheapest way to go from Jacksonville, FL to Florence, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Jacksonville, FL by bus?

Bus from Florence, SC, US to Jacksonville, FL

You can also go to Florence, SC, US by train

Train from Jacksonville, FL to Florence, SC, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

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