Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Panama City Beach Station | Downtown Transit Center | Cheapest | ||||
 | Bus | Panama City Beach Station | Indianapolis Bus Station | Fastest | ||||
| Bus | Panama City Beach Station | Indianapolis Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Panama City Beach Station | Downtown Transit Center | No tags | ||||
| Bus | Panama City Beach Station | Indianapolis Bus Station | No tags |
Last refresh of the prices: Yesterday at 8:22 PM CST.
Get from Panama City to Indianapolis
The journey takes about 1 day, 6 hours 5 minutes, and with fares starting at just R 2 359, it presents an excellent value for a comfortable ride.
Where are the popular stops in Panama City and Indianapolis?
Stops in Indianapolis
- A350 S Illinois St, Indianapolis, IN 46225
Compare bus companies
Based on 87496 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at R 2 359
Frequently asked questions about travelling from Panama City, US to Indianapolis by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Panama City to Indianapolis?
The cheapest bus tickets from Panama City to Indianapolis start at R 2 359. The average price for this route is around R 3 546. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Panama City to Indianapolis?
The average bus journey time from Panama City to Indianapolis is 1d 6h, covering a distance of 1066 km. The fastest bus gets you there in 22h 15m and is operated by Greyhound.
Which bus companies service the Panama City to Indianapolis route?
Several major bus companies operate on this route with 5 buses available per day.
What is the earliest and latest departure time for the bus from Panama City to Indianapolis?
The earliest bus departs from Panama City to Indianapolis at 07:30. And the latest bus departs at 21:40.
What are the CO₂ emissions for the bus trip from Panama City to Indianapolis?
A bus trip from Panama City to Indianapolis produces an estimated 27 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Panama City, US to Indianapolis was searched and found on 15 Jan 2026 with a price of R 2 188To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Indianapolis as early as possible.
You can expect to pay from R 2 188 to R 3 164 for a bus ticket from Panama City, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at R 2 188, which is on 2026-01-15.
