Find coaches from Panama City, US to Indianapolis

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Bus Panama City to Indianapolis: Trip Overview

Average ticket priceUS$139
Average bus trip duration22h 15m
Number of daily buses2
Earliest bus departure12:50
Distance661 miles

Panama City to Indianapolis Bus

Busbud helps you find a bus from Panama City to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Panama City to Indianapolis from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Indianapolis from Panama City, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Panama City, US - Indianapolis

  1. What is the cheapest way to go from Panama City to Indianapolis?

    The price for a coach ticket from Panama City to Indianapolis starts at US$102, though the average is US$139. The exact cost can vary based on different factors such as the time of travel, the day of the week, and the coach service provider. Compare the prices and amenities offered by each company on Busbud and find the best deals and offers.

  2. How long does it take to travel from Panama City to Indianapolis by bus?

    The coach journey between Panama City and Indianapolis lasts about 22h 15m. The quickest coach journey typically takes 22h 15m. However, please keep in mind that your specific travel time may vary due to the prevailing traffic conditions along the route.

  3. When is the first coach from Panama City to Indianapolis?

    The first coach to Indianapolis from Panama City departs at 12:50. Keep in mind that departure times might change on weekends and holidays.

  4. How far is Indianapolis from Panama City by coach?

    The journey from Panama City to Indianapolis by coach covers an approximate distance of 664 miles (1071 km).

  5. Is there a way to reach Indianapolis from Panama City without flying?

    You can choose the coach to travel this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.

  6. Is there am overnight bus from Panama City to Indianapolis?

    Yes, you can find buses leaving until 12:50 and arriving the next day. Remember to bring along some essentials like a snuggly blanket and a few treats for a comfortable trip.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
31/05
US$228
01/06
No data
Today
No data
03/06
US$157
04/06
No data
05/06
No data
06/06
No data
07/06
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busbud logoThe cheapest trip from Panama City to Indianapolis was searched and found on 3 Jun 2025 with a price of US$157

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City to Indianapolis as early as possible.

You can expect to pay from US$157 to US$228 for a bus ticket from Panama City to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at US$157, which is on 2025-06-03.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Panama City and Indianapolis!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Panama City to Indianapolis, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Panama City to Indianapolis.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Panama City to Indianapolis.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Will you be returning to Panama City by bus?

Bus from Panama City to Indianapolis

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