Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Panama City Beach Station | Downtown Transit Center | Cheapest | ||||
 | Bus | Panama City Beach Station | Indianapolis Bus Station | Fastest | ||||
| Bus | Panama City Beach Station | Indianapolis Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Panama City Beach Station | Downtown Transit Center | No tags | ||||
| Bus | Panama City Beach Station | Indianapolis Bus Station | No tags |
Last refresh of the prices: Yesterday at 8:22 PM CST.
Get from Panama City to Indianapolis
The journey takes about 1 day, 6 hours 5 minutes, and with fares starting at just $200, it presents an excellent value for a comfortable ride.
Where are the popular stops in Panama City and Indianapolis?
Stops in Indianapolis
- A350 S Illinois St, Indianapolis, IN 46225
Compare bus companies
Based on 87495 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $200
Frequently asked questions about travelling from Panama City, US to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Panama City to Indianapolis?
The cheapest bus tickets from Panama City to Indianapolis start from $200. The average price for this route is around $301. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Panama City to Indianapolis?
The average bus travel time from Panama City to Indianapolis is 1d 6h, covering a distance of 1066 km. The quickest bus can get you there in 22h 15m and is operated by Greyhound.
Which bus companies service the Panama City to Indianapolis route?
Several major bus companies operate on this route with 5 buses available per day.
What are the earliest and latest departure times for the bus from Panama City to Indianapolis?
The earliest bus departs from Panama City to Indianapolis at 7:30am. And the latest bus departs at 9:40pm.
What are the CO₂ emissions for the bus trip from Panama City to Indianapolis?
A bus trip from Panama City to Indianapolis generates an estimated 27 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Panama City, US to Indianapolis was searched and found on Jan 15, 2026 with a price of $186To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Indianapolis, as early as possible.
You can expect to pay from $186 to $268 for a bus ticket from Panama City, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $186 which is on 2026-01-15.
