Bus Tickets from Panama City, US to Indianapolis

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Bus Panama City to Indianapolis: Trip Overview

Average ticket price$139
Average bus trip duration22h 15m
Number of daily buses2
Earliest bus departure12:50pm
Distance661 miles (1066 km)

Panama City to Indianapolis Bus

Busbud helps you find a bus from Panama City to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Panama City to Indianapolis from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Indianapolis from Panama City, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Panama City, US - Indianapolis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05/29
No data
05/30
No data
Today
$228
06/01
No data
06/02
No data
06/03
$157
06/04
No data
06/05
No data
busbud logoThe cheapest trip from Panama City to Indianapolis was searched and found on Jun 3, 2025 with a price of $157

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City to Indianapolis, as early as possible.

You can expect to pay from $157 to $228 for a bus ticket from Panama City to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $157 which is on 2025-06-03.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Panama City and Indianapolis!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Panama City to Indianapolis, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Panama City to Indianapolis.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Panama City to Indianapolis.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Will you be returning to Panama City by bus?

Bus from Panama City to Indianapolis

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