Find coaches from Panama City, US to Key West

Next departures

Next departures from Panama City to Key West on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Panama City Beach Station
Key West Bus StationCheapest
Greyhound Lines, Inc.
Panama City Beach Station
Key West Bus StationFastest

Last refresh of the prices: Last Wednesday at 11:37 PM CDT.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Get from Panama City to Key West

busbud logoThis route is served by bus only

The journey takes about 1 day, 1 hour 40 minutes, and with fares starting at just US$128, it presents an excellent value for a comfortable ride.

2bus per day
1d 1hAverage duration
742 kmDistance
19kgCO₂ emissions

Bus Panama City, US to Key West: Trip Overview

Average ticket priceUS$128
Average bus trip duration1d 1h
Number of daily buses2
Earliest bus departure12:50
Distance741 km
Latest bus departure14:15

Panama City to Key West Bus

With Busbud, comparing and booking tickets for a bus from Panama City to Key West is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Panama City to Key West.

Discover how much the bus trip from Panama City to Key West will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Panama City, US - Key West

  1. How much does a bus ticket from Panama City to Key West cost?

    The bus ticket price from Panama City to Key West starts at US$128. The best way to find cheap bus tickets from Panama City to Key West is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Panama City to Key West?

    The average travel time between Panama City and Key West is around 1d 1h, although the fastest bus will take about 1d 1h. This is the time it takes to travel the 733 km that separates the two cities.

  3. How many daily bus connections are there between Panama City and Key West?

    The number of buses from Panama City to Key West can differ depending on the day of the week. On average, there are 2 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Panama City to Key West by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Panama City to Key West?

    When taking the bus from Panama City to Key West, you can travel comfortably and safely with Greyhound.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
29/10
No data
30/10
No data
Today
US$158
01/11
No data
02/11
No data
03/11
No data
04/11
No data
05/11
No data
busbud logoThe cheapest trip from Panama City, US to Key West was searched and found on 31 Oct 2025 with a price of US$158

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Key West as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Panama City to Key West.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Panama City to Key West.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Panama City to Key West will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Panama City to Key West while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Panama City, US by bus?

Bus from Key West to Panama City, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Panama City

Buses Leaving from Panama City

Buses Going to Panama City

Popular Buses Connecting Key West

Buses Leaving from Key West

Buses Going to Key West