Bus Tickets from Panama City, US to Key West

Next departures

Next departures for Panama City to Key West on October 31
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
    		Panama City Beach Station
    		Key West Bus StationCheapestFastest

    Last refresh of the prices: Last Wednesday at 11:37 PM CDT.

    Accepted payments

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    Get from Panama City to Key West

    This route is served by bus only

    The journey takes about 1 day, 1 hour 40 minutes, and with fares starting at just US$128, it presents an excellent value for a comfortable ride.

    2bus per day
    1d 1hAverage Duration
    742 kmDistance
    19kgCO₂ emissions

    Bus Panama City, US to Key West: Trip Overview

    Average Ticket PriceUS$128
    Average Bus Trip Duration1d 1h
    Number of daily buses2
    Earliest bus departure12:50pm
    Distance741 km
    Latest bus departure2:15pm

    Panama City to Key West Bus

    With Busbud, comparing and booking tickets for a bus from Panama City to Key West is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

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    Frequently asked questions on the trip Panama City, US - Key West

    1. What is the distance between Panama City and Key West?

      Panama City and Key West are 733 km (455 miles) apart.

    2. What are the departure and arrival locations for buses traveling from Panama City to Key West?

      Buses departing from Panama City Greyhound Bus Station in Panama City will take you to Caroline St in Key West.

    Find cheapest prices for buses

    Price is for a one-way ticket for one passenger and based on past searches.

    Best price found
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    US$158
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    busbud logoThe cheapest trip from Panama City, US to Key West was searched and found on Oct 31, 2025 with a price of US$158

    To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Key West, as early as possible.

    About Bus Travel

    Bus Travel Tips

    Meet and talk to locals at the bus stations while travelling from Panama City to Key West.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

    From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Panama City to Key West.

    Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Panama City to Key West will emit less CO2 than a car or an airplane.

    Tune out to the fine sounds of your best music playlist on your bus trip from Panama City to Key West while indulging in miles on end of beautiful scenic views.

    Did you know?

    One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

    Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

    It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

    Will you be returning to Panama City, US by bus?

    Bus from Key West to Panama City, US

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