Bus Tickets from Panama City, US to Key West

Previously seen trips

Next departures for Panama City to Key West on November 1
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
    		Panama City Beach Station
    		Key West Bus StationNo tags
    Greyhound + FlixBus
      		Panama City Beach Station
      		Caroline StNo tags
      Greyhound + FlixBus
        		Panama City Beach Station
        		Key West Bus StationNo tags
        FlixBus + Greyhound
          		Panama City Beach Station
          		Caroline StNo tags
          Greyhound + FlixBus
            		Panama City Beach Station
            		Caroline StNo tags

            Accepted payments

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            Get from Panama City to Key West

            This route is served by bus only

            The journey takes about 1 day, 1 hour 40 minutes and with fares starting at just $128, it presents an excellent value for a comfortable ride.

            2bus per day
            1d 1hAverage Duration
            460 milesDistance
            19kgCO₂ emissions

            Bus Panama City, US to Key West: Trip Overview

            Average ticket price$128
            Average bus trip duration1d 1h
            Number of daily buses2
            Earliest bus departure12:50pm
            Distance460 miles (741 km)
            Latest bus departure2:15pm

            Panama City to Key West Bus

            With Busbud, comparing and booking tickets for a bus from Panama City to Key West is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

            We make it our job to connect you with the most dependable bus companies that cover bus service from Panama City to Key West.

            Discover how much the bus trip from Panama City to Key West will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

            Frequently asked questions for your trip Panama City, US - Key West

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            10/29
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            10/30
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            Today
            $158
            11/01
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            11/02
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            11/03
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            11/04
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            11/05
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            busbud logoThe cheapest trip from Panama City, US to Key West was searched and found on Oct 31, 2025 with a price of $158

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Key West, as early as possible.

            About Bus Travel

            Bus Travel Tips

            Meet and talk to locals at the bus stations while traveling from Panama City to Key West.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

            From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Panama City to Key West.

            Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Panama City to Key West will emit less CO2 than a car or an airplane.

            Tune out to the fine sounds of your best music playlist on your bus trip from Panama City to Key West while indulging in miles on end of beautiful scenic views.

            Did you know?

            One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

            Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

            It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

            Will you be returning to Panama City, US by bus?

            Bus from Key West to Panama City, US

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