Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Rome Tiburtina Bus Station | Florenc | CheapestFastest |
Last refresh of the prices: Last Wednesday at 1:56 PM CEST.
Get from Rome to Prague
The journey takes about 1 day, 40 minutes, and with fares starting at just R 1 192, it presents an excellent value for a comfortable ride.
Where are the popular stops in Rome and Prague?
Stops in Rome
- B
Rome Tiburtina Bus Station
Largo Guido Mazzoni, 3, 00162 Roma, Italy - D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Stops in Prague
- A
PRG Airport
Aviatická, 161 08, Praha 6, Czechia - B
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - C
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic - D
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia - E
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic - F
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
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Frequently asked questions about travelling from Rome to Prague by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Rome to Prague?
The cheapest bus tickets from Rome to Prague start at R 1 192. The average price for this route is around R 2 363. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Rome to Prague?
The average bus journey time from Rome to Prague is 1d , covering a distance of 928 km. The fastest bus gets you there in 19h 55m and is operated by FlixBus.
Which bus companies service the Rome to Prague route?
What is the earliest and latest departure time for the bus from Rome to Prague?
The earliest bus departs from Rome to Prague at 01:05. And the latest bus departs at 23:50.
What are the CO₂ emissions for the bus trip from Rome to Prague?
A bus trip from Rome to Prague produces an estimated 23.176175 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Rome to Prague?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1078 reviews.
Which bus company has the best Wi-Fi from Rome to Prague?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.9.
Which bus company offers the most punctual service from Rome to Prague?
According to Busbud traveller reviews, the most punctual bus company on this route is RegioJet, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Rome to Prague?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Prague was searched and found on 07 Jun 2026 with a price of R 1 293To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Prague as early as possible.
You can expect to pay from R 1 293 to R 4 772 for a bus ticket from Rome to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 294, which is on 2026-06-10.
