Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Rome Tiburtina Bus Station | PRG Airport | Cheapest | ||||
| Bus | Rome Anagnina | Prague (Central Bus Station Florenc) | Fastest | ||||
| Bus | Aeroporto Ciampino Airport (CIA) | PRG Airport | No tags | ||||
| Bus | Aeroporto Ciampino Airport (CIA) | PRG Airport | No tags | ||||
| Bus | Rome Tiburtina Bus Station | PRG Airport | No tags |
Last refresh of the prices: Yesterday at 15:19 CET.
Compare 2 ways to travel from Rome to Prague
Among the sustainable travel choices, the carpool stands out as a good way to reach Prague. The journey takes about 14 hours and with fares starting at just £50, it presents an excellent value for a comfortable ride.
| Average price | Average duration | CO₂ emissions | Actions | |
|---|---|---|---|---|
| Average price£40 - £203 | Average duration1d | 23kg CO₂e | ||
Carpool | Average price£50 - £59 | Average duration14h | 39kg CO₂e |
Where are the popular stops in Rome and Prague?
Stops in Rome
- ALargo Guido Mazzoni, 3, 00162 Roma, Italy
- D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Stops in Prague
- AKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- BAviatická, 161 08, Praha 6, Czechia
- CTomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- DChlumecká, 198 00 Praha 20, Czech Republic
- E
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - F300/8 Wilsonova, 110 00 Praha, Czechia
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Frequently asked questions about travelling by bus from Rome to Prague
What's the distance between Rome and Prague by coach?
The journey from Rome to Prague by coach covers an approximate distance of 573 miles (925 km).
What is the best way to go from Rome to Prague without flying?
You can choose the coach to travel this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Prague was searched and found on 26 Nov 2025 with a price of £52To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Prague as early as possible.
You can expect to pay from £52 to £185 for a bus ticket from Rome to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at £52, which is on 2025-11-26.
