Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound + FlixBus | Bus | Des Moines (Subway) | Columbus (E Mound St) | No tags | ||||
FlixBus + Greyhound | Bus | Des Moines (Subway) | 100 E Rich St | No tags | ||||
Greyhound + FlixBus | Bus | Des Moines (Subway) | Columbus (Ohio State University) | No tags | ||||
 | Bus | Des Moines (Subway) | Columbus (E Mound St) | No tags | ||||
Greyhound + FlixBus | Bus | Des Moines (Subway) | 100 E Rich St | No tags |
Get from Des Moines to Columbus
The journey takes about 18 hours 5 minutes and with fares starting at just $87, it presents an excellent value for a comfortable ride.
Where are the popular stops in Des Moines and Columbus?
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Stops in Columbus
- A
Columbus Bus Station
25 E Rich St, Columbus, OH 43205, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Des Moines to Columbus, OH by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Des Moines to Columbus?
The cheapest bus tickets from Des Moines to Columbus start from $87. The average price for this route is around $106. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Des Moines to Columbus?
The average bus trip duration from Des Moines to Columbus is 18h 5m, covering a distance of 565 miles (911 km). The quickest bus can get you there in 18h 5m and is operated by Greyhound.
Which bus companies service the Des Moines to Columbus route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Des Moines to Columbus?
The earliest bus departs from Des Moines to Columbus at 5:30am. And the latest bus departs at 4:20pm.
What are the CO₂ emissions for the bus trip from Des Moines to Columbus?
A bus trip from Des Moines to Columbus generates an estimated 22.774025 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Columbus, OH was searched and found on Apr 13, 2026 with a price of $90To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Columbus, OH, as early as possible.
You can expect to pay from $90 to $104 for a bus ticket from Des Moines to Columbus, OH based on the last 2 days. You can expect to find the cheapest price for the trip at $90 which is on 2026-04-13.
Top traveled bus routes
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