Bus Tickets from Key Largo to Gainesville, FL

Previously seen trips

Next departures for Key Largo to Gainesville on October 4
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
Key Largo
Rosa Parks StationNo tags
Greyhound + FlixBus
Key Largo
Rosa Parks StationNo tags
Greyhound
Key Largo
Gainesville Bus StopNo tags

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Key Largo to Gainesville, FL: Trip Overview

Average ticket price$70
Average bus trip duration12h 45m
Number of daily buses3
Earliest bus departure12:10pm
Distance335 miles (539 km)
Latest bus departure7:40pm

Key Largo to Gainesville Bus

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Frequently asked questions for your trip Key Largo - Gainesville, FL

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/02
$52
10/03
No data
Today
No data
10/05
No data
10/06
No data
10/07
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10/08
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10/09
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busbud logoThe cheapest trip from Key Largo to Gainesville, FL was searched and found on Oct 2, 2025 with a price of $52

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Key Largo to Gainesville, FL, as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Key Largo to Gainesville but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Key Largo to Gainesville.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Key Largo to Gainesville will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Key Largo to Gainesville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

Will you be returning to Key Largo by bus?

Bus from Gainesville, FL to Key Largo

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