Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Parcheggio Via Pietransantina | Terminal Bus Palermo | Cheapest | ||||
| Bus | Parcheggio Via Pietransantina | Terminal Bus Palermo | Fastest | ||||
| Bus | park Aurelia | Terminal Bus Palermo | No tags |
Last refresh of the prices: Today at 3:29 PM CEST.
Get from Pisa to Palermo
The journey takes about 22 hours 5 minutes and with fares starting at just $92, it presents an excellent value for a comfortable ride.
Where are the popular stops in Pisa and Palermo?
Stops in Pisa
- AVia Pietrasantina, 56123 Pisa PI
- C
Piazza della Stazione
Piazza della Stazione, 1, 56125 Pisa PI, Italy
Stops in Palermo
- AVia Tommaso Fazello, 16, 90123 Palermo PA, Italy
- BPunta Raisi, 90145, Palermo
- CPiazza Cairoli, 8-14, 90123 Palermo, Italy
- D90143 Palermo PA, Italy
- E
Via Paolo Balsamo, 31
Via Paolo Balsamo, 23-31, 90123 Palermo, Italy - F
Piazza Ruggero Settimo, 12
Piazza Ruggero Settimo, 12C, 90139 Palermo, Italy
Compare bus companies
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Pisa to Palermo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Pisa to Palermo?
The cheapest bus tickets from Pisa to Palermo start from $92. The average price for this route is around $114. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Pisa to Palermo?
The average bus trip duration from Pisa to Palermo is 22h 5m, covering a distance of 417 miles (673 km). The quickest bus can get you there in 21h 35m and is operated by FlixBus.
Which bus companies service the Pisa to Palermo route?
Several major bus companies operate on this route with 2 buses available per day.
What is the earliest and latest departure time for the bus from Pisa to Palermo?
The earliest bus departs from Pisa to Palermo at 6:05am. And the latest bus departs at 5:25pm.
What are the CO₂ emissions for the bus trip from Pisa to Palermo?
A bus trip from Pisa to Palermo generates an estimated 16.806575000000002 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pisa to Palermo was searched and found on May 30, 2026 with a price of $131To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pisa to Palermo, as early as possible.
You can expect to pay from $131 to $229 for a bus ticket from Pisa to Palermo based on the last 2 days. You can expect to find the cheapest price for the trip at $131 which is on 2026-05-30.
