What is the distance between Santander and Lyon?

The distance between the two cities is 454 miles (732 km).

What are the departure and arrival stations when taking the bus from Santander to Lyon?

If you're headed to Lyon from Santander, chances are that your bus will depart from Calle Navas de Tolosa, 2 and arrive at Perrache. These are the primary departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.

What are the best sights and things to do in Lyon?

Once in Lyon, you can start exploring the city and discover its surroundings. The top sights and things to do are Boat Trips, La Place des Terreaux/Bartholdi Fountain, Basilique Notre Dame de Fourviere, The Old Town and Musée des Tissus.

Bus Santander to Lyon from $34 | Refundable Tickets

Next bus departures

Next departures for Santander to Lyon on November 27
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	9:00am	SANTANDER	19h 55m	4:55am	LYON	Cheapest
Bus	6:50pm	Santander (Estacion de Autobuses)	15h 40m	10:30am	Lyon	Fastest
Bus	9:00am	SANTANDER	19h 55m	4:55am	LYON	No tags
Bus	6:50pm	Santander (Estacion de Autobuses)	16h	10:50am	Perrache	No tags
Bus	6:50pm	Santander (Estacion de Autobuses)	17h 35m	12:25pm	Aéroport LYS	No tags

Last refresh of the prices: Today at 3:30 PM CET.

Compare 2 ways to go from Santander to Lyon

We recommend carpooling

Among the sustainable travel choices, the carpool stands out as the good way to reach Lyon. The journey takes about 10 hours 50 minutes and with fares starting at just $83, it presents an excellent value for a comfortable ride.

1carpool per day

10h 50mAverage Duration

454 milesDistance

31kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$72 - $185	Average Duration19h 55m	CO₂ emissions 18kg CO₂e
Carpool	Average Price$83 - $83	Average Duration10h 50m	CO₂ emissions 31kg CO₂e

Where are the popular stops in Santander and Lyon?

Stops in Santander

A
Calle Navas de Tolosa, 2
Calle Navas de Tolosa, 2, 39002 Santander, Cantabria, Spain
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B
Santander Airport
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C
Av. de los Castros 43A
Av. de los Castros 43A, 39005 Santander, Cantabria, Spain
D
Calle Camarreal-Ojaiz
Calle Camarreal-Ojaiz, 52, 39011 Santander, Cantabria, Spain
E
Av. de Pontejos
Av. de Pontejos, 33A, 39005 Santander, Cantabria, Spain
F
Estación Marítima
39002 Santander, Cantabria, Spain

Stops in Lyon

A
Perrache
Rue de Esplanade, 69002 Lyon, France
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B
Lyon Airport
Visit page
C
Lyon
8 Rue de la Paix, 69700 Givors, France
D
Quai de Saoune
4 Cours de Verdun Rambaud, 69002 Lyon, France
E
Villeurbanne INSA
20 Avenue Albert Einstein, 69100 Villeurbanne, France
F
Les Charrières
Les Charrières, 69570 Dardilly, France
Visit page

Compare bus companies

FlixBus

3.5/511,449 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

ALSA

4.5/560,832 reviews

Staff4.7

Timeliness4.4

Cleanliness4.7

Wifi3.5

BlaBlaCar Bus

3.5/511,161 reviews

Staff4.4

Timeliness3.6

Cleanliness4.3

Wifi2.6

FR bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Rede Expressos, Trenitalia

Frequently asked questions about traveling from Santander to Lyon by bus

What is the distance between Santander and Lyon?
What are the departure and arrival stations when taking the bus from Santander to Lyon?
What are the best sights and things to do in Lyon?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/24

$67

11/25

No data

Today

$55

11/27

$55

11/28

$34

11/29

$55

11/30

$49

12/01

$49

The cheapest trip from Santander to Lyon was searched and found on Nov 28, 2025 with a price of $34

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santander to Lyon, as early as possible.

You can expect to pay from $34 to $136 for a bus ticket from Santander to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at $34 which is on 2025-11-28.