How much is the train ticket from Greenville to Indianapolis?

The cheapest train tickets from Greenville to Indianapolis start from $176. The average price for this train route is around $196. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the train journey from Greenville to Indianapolis?

The average train ride duration from Greenville to Indianapolis is 1d 2h, covering a distance of 396 miles (638 km). The quickest train can get you there in 1d 2h and is operated by Amtrak .

Which train operators service the Greenville to Indianapolis route?

Several major train operators operate on this route with 1 trains available per day.

What is the earliest and latest departure time for the train from Greenville to Indianapolis?

The earliest train departs from Greenville to Indianapolis at 2:23am. And the latest train departs at 2:23am.

Train Greenville to Indianapolis from $133 | Refundable Tickets

Previously seen trips

Next departures for Greenville to Indianapolis on January 19
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Train	2:23am	Greenville Station	1d 2h	5:15am	Greyhound Amtrak Station	No tags
Train	2:23am	Greenville Station	1d 2h	5:15am	Greyhound Amtrak Station	No tags
Train	2:23am	Greenville Station	1d 2h	5:15am	Greyhound Amtrak Station	No tags
Train	2:23am	Greenville Station	1d 2h	5:15am	Greyhound Amtrak Station	No tags
Train	2:23am	Greenville Station	1d 2h	5:15am	Greyhound Amtrak Station	No tags

Compare 2 ways to go from Greenville to Indianapolis

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as the good way to reach Indianapolis. The journey takes about 17 hours 40 minutes and with fares starting at just $86, it presents an excellent value for a comfortable ride.

6bus per day

17h 40mAverage Duration

401 milesDistance

16kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$86 - $254	Average Duration17h 40m	CO₂ emissions 16kg CO₂e
Train	Average Price$176 - $258	Average Duration1d 2h	CO₂ emissions 58kg CO₂e

Train Companies

Amtrak

4/55,742 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

Based on 5742 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $176

US train companies:Amtrak, Trenitalia, Renfe, VIA Rail Canada, Amtrak Acela, NS Nederlandse Spoorwegen, Iryo

Frequently asked questions about traveling from Greenville, SC to Indianapolis by train

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the train ticket from Greenville to Indianapolis?
The cheapest train tickets from Greenville to Indianapolis start from $176. The average price for this train route is around $196. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the train journey from Greenville to Indianapolis?
The average train ride duration from Greenville to Indianapolis is 1d 2h, covering a distance of 396 miles (638 km). The quickest train can get you there in 1d 2h and is operated by Amtrak.
Which train operators service the Greenville to Indianapolis route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the train from Greenville to Indianapolis?
The earliest train departs from Greenville to Indianapolis at 2:23am. And the latest train departs at 2:23am.

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

01/16

$186

01/17

No data

Today

No data

01/19

No data

01/20

No data

01/21

$133

01/22

No data

01/23

No data

The cheapest trip from Greenville, SC to Indianapolis was searched and found on Jan 21, 2026 with a price of $133

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Greenville, SC to Indianapolis, as early as possible.

You can expect to pay from $133 to $899 for a train ticket from Greenville, SC to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $133 which is on 2026-01-21.