Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Old Town San Diego | Gateway Station | Cheapest | ||||
| Train | Old Town San Diego | Gateway Station | Fastest | ||||
| Train | Santa Fe Depot | Gateway Station | No tags | ||||
| Train | Santa Fe Depot | Gateway Station | No tags | ||||
| Train | Santa Fe Depot | Gateway Station | No tags |
Last refresh of the prices: Last Saturday at 1:35 PM PST.
Compare 2 ways to go from San Diego to St. Louis
Among the sustainable travel choices, the Bus stands out as a good way to reach St. Louis. The journey takes about 1 day, 22 hours 40 minutes and with fares starting at just $162, it presents an excellent value for a comfortable ride.
Train Companies
Based on 5754 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $202
Frequently asked questions about traveling from San Diego, CA, US to St. Louis by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from San Diego to St. Louis?
The cheapest train tickets from San Diego to St. Louis start from $202. The average price for this train route is around $294. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the train journey from San Diego to St. Louis?
The average train ride duration from San Diego to St. Louis is 2d 6h, covering a distance of 1559 miles (2514 km). The quickest train can get you there in 1d 22h and is operated by Amtrak.
Which train operators service the San Diego to St. Louis route?
Several major train operators operate on this route with 4 trains available per day.
What is the earliest and latest departure time for the train from San Diego to St. Louis?
The earliest train departs from San Diego to St. Louis at 2:01pm. And the latest train departs at 4:10pm.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to St. Louis was searched and found on Feb 6, 2026 with a price of $194To save money and be sure you have the best seat, it's a good idea to buy your train tickets from San Diego, CA, US to St. Louis, as early as possible.
You can expect to pay from $194 to $1,482 for a train ticket from San Diego, CA, US to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $194 which is on 2026-02-06.
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