How much is the train ticket from Greenville to Indianapolis?

The cheapest train tickets from Greenville to Indianapolis start from $161. The average price for this train route is around $220. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the train journey from Greenville to Indianapolis?

The average train ride duration from Greenville to Indianapolis is 1d 3h, covering a distance of 396 miles (638 km). The quickest train can get you there in 1d 3h and is operated by Amtrak .

Which train operators service the Greenville to Indianapolis route?

Several major train operators operate on this route with 1 trains available per day.

What is the earliest and latest departure time for the train from Greenville to Indianapolis?

The earliest train departs from Greenville to Indianapolis at 2:23am. And the latest train departs at 2:23am.

Train Greenville to Indianapolis from $154 | Refundable Tickets

Next train departures

Next departures for Greenville to Indianapolis on April 10
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Train	2:23am	Greenville Station	1d 3h	5:55am	Greyhound Amtrak Station	CheapestFastest
	Train	2:23am	Greenville Station	1d 3h	5:55am	Greyhound Amtrak Station	No tags

Last refresh of the prices: Today at 11:25 AM EDT.

Compare 2 ways to go from Greenville to Indianapolis

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Indianapolis. The journey takes about 19 hours 10 minutes and with fares starting at just $83, it presents an excellent value for a comfortable ride.

6bus per day

19h 10mAverage Duration

401 milesDistance

16kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$83 - $250	Average Duration19h 10m	CO₂ emissions 16kg CO₂e
Train	Average Price$161 - $334	Average Duration1d 3h	CO₂ emissions 58kg CO₂e

Train Companies

Amtrak

4.1/55,784 reviews

Staff4.7

Timeliness3.8

Cleanliness4.5

Wifi3.6

Based on 5784 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $161

US train companies:Amtrak, Trenitalia, Renfe, VIA Rail Canada, Amtrak Acela, NS Nederlandse Spoorwegen, Iryo

Frequently asked questions about traveling from Greenville, SC to Indianapolis by train

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the train ticket from Greenville to Indianapolis?
The cheapest train tickets from Greenville to Indianapolis start from $161. The average price for this train route is around $220. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the train journey from Greenville to Indianapolis?
The average train ride duration from Greenville to Indianapolis is 1d 3h, covering a distance of 396 miles (638 km). The quickest train can get you there in 1d 3h and is operated by Amtrak.
Which train operators service the Greenville to Indianapolis route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the train from Greenville to Indianapolis?
The earliest train departs from Greenville to Indianapolis at 2:23am. And the latest train departs at 2:23am.

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

04/07

No data

04/08

No data

Today

No data

04/10

$191

04/11

No data

04/12

No data

04/13

No data

04/14

No data

The cheapest trip from Greenville, SC to Indianapolis was searched and found on Apr 10, 2026 with a price of $191

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Greenville, SC to Indianapolis, as early as possible.

You can expect to pay from $191 to $806 for a train ticket from Greenville, SC to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $191 which is on 2026-04-10.