Next departures for Prague to Brussels on November 20
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Train
Hlavní nádraží
Brussels South/Midi Train Station
CheapestFastest
Train
Hlavní nádraží
Brussels South/Midi Train Station
No tags
Train
Hlavní nádraží
Brussels South/Midi Train Station
No tags
Train
Hlavní nádraží
Brussels South/Midi Train Station
No tags
Train
Hlavní nádraží
Brussels South/Midi Train Station
No tags
Next departures for Prague to Brussels on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Train
Hlavní nádraží
Brussels South/Midi Train Station
CheapestFastest
Train
Hlavní nádraží
Brussels South/Midi Train Station
No tags
Train
Hlavní nádraží
Brussels South/Midi Train Station
No tags
Train
Hlavní nádraží
Brussels South/Midi Train Station
No tags
Train
Hlavní nádraží
Brussels South/Midi Train Station
No tags
Last refresh of the prices: Today at 11:42 AM CET.
Compare 2 ways to go from Prague to Brussels
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Brussels. The journey takes about 18 hours 40 minutes and with fares starting at just $44, it presents an excellent value for a comfortable ride.
Brussel-Centraal, Carrefour de l'Europe, 1000 Bruxelles, Belgium
Frequently asked questions about traveling from Prague to Brussels by train
How much does a train ticket from Prague to Brussels cost?
The average train ticket price from Prague to Brussels is $126. The best way to find train tickets from Prague to Brussels is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the train trip from Prague to Brussels?
A train trip between Prague and Brussels is around 15h 21m, although the fastest train will take about 11h 3m. This is the time it takes to travel the 446 miles that separates the two cities.
How many daily trains are there between Prague and Brussels?
The number of trains from Prague to Brussels can differ depending on the day of the week. On average, there are 4. Some trains are direct while others have layovers. Simplify your train trip from Prague to Brussels by comparing and selecting the train that fits your travel style and budget on Busbud.
What are the departure and arrival stations for a train from Prague to Brussels?
Trains traveling between Prague and Brussels leave from Hlavní nádraží or Florenc and arrive at Brux-Nord, Brussels South (Gare du Midi), Bruxelles / Brussels Central.
What are the best sights and things to do in Brussels?
Once in Brussels, you can explore the city. The top sights and things to do are Couleur Café Music Festival, Bruxelles Les Bains - A beach in Brussels!, Visit the Laeken Royal Greenhouses in Brussels, The Iris events, The Ommegang, Brussels' oldest historical pageant.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/16
$227
11/17
No data
Today
$155
11/19
No data
11/20
$250
11/21
No data
11/22
No data
11/23
$203
The cheapest trip from Prague to Brussels was searched and found on Nov 18, 2025 with a price of $155
To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Prague to Brussels, as early as possible.
You can expect to pay from $155 to $1,132 for a train ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $203 which is on 2025-11-23.
The cheapest trip from Prague to Brussels was searched and found on Nov 18, 2025 with a price of $155
