Next train departures

Next departures for Prague to Brussels on December 21
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	Cheapest
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	Fastest
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	No tags
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	No tags
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	No tags

Next departures for Prague to Brussels on December 23
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	Cheapest
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	Fastest
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	No tags
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	No tags
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	No tags

Next departures for Prague to Brussels on December 25
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	Cheapest
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	Fastest
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	No tags
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	No tags
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	No tags

Next departures for Prague to Brussels on December 27
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
EuroCity Train + Deutsche Bahn ICE + InterCity	Train	6:31pm	Hlavní nádraží	15h 18m	9:49am	Schaarbeek	Cheapest
EuroCity Train + Deutsche Bahn ICE + InterCity	Train	6:31pm	Hlavní nádraží	15h 7m	9:38am	Brussels Central Train Station	Fastest
EuroCity Train + Deutsche Bahn ICE + InterCity	Train	6:31pm	Hlavní nádraží	15h 18m	9:49am	Schaarbeek	No tags
EuroCity Train + Deutsche Bahn ICE + InterCity	Train	6:31pm	Hlavní nádraží	15h 18m	9:49am	Schaarbeek	No tags
EuroCity Train + Deutsche Bahn ICE + InterCity	Train	6:31pm	Hlavní nádraží	15h 7m	9:38am	Brussels Central Train Station	No tags

Last refresh of the prices: Today at 12:54 PM CET.

Compare 2 ways to go from Prague to Brussels

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Brussels. The journey takes about 18 hours 40 minutes and with fares starting at just $44, it presents an excellent value for a comfortable ride.

17bus per day

18h 40mAverage Duration

440 milesDistance

18kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$44 - $247	Average Duration18h 40m	CO₂ emissions 18kg CO₂e
Train	Average Price$62 - $302	Average Duration15h 18m	CO₂ emissions 17kg CO₂e

Where are the popular train stations and stops in Prague and Brussels?

Prague

A
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
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B
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
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C
PRG Airport
Aviatická, 161 08, Praha 6, Czechia
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D
Praha hl.n
Prague Main Railway Station, 120 00 Praha-Praha 2, Czechia
E
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic
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F
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
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Brussels

A
Brux-Nord
Boulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
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B
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium
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C
Bruxelles / Brussels Central
Brussel-Centraal, Carrefour de l'Europe, 1000 Bruxelles, Belgium

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12/19

No data

12/20

No data

Today

$156

12/22

No data

12/23

$109

12/24

No data

12/25

$156

12/26

No data

The cheapest trip from Prague to Brussels was searched and found on Dec 23, 2025 with a price of $109

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Prague to Brussels, as early as possible.

You can expect to pay from $109 to $1,141 for a train ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $109 which is on 2025-12-23.