Next train departures

Next departures for Prague to Brussels on April 28
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	Cheapest
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	Fastest
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	No tags
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	No tags
Train	6:00pm	Hlavní nádraží	15h 27m	9:27am	Brussels South/Midi Train Station	No tags

Last refresh of the prices: Last Thursday at 6:10 PM CEST.

Compare 2 ways to go from Prague to Brussels

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Brussels. The journey takes about 15 hours 22 minutes and with fares starting at just CLP 73,182, it presents an excellent value for a comfortable ride.

2train per day

15h 22mAverage Duration

446 milesDistance

17kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average PriceCLP 40,300 - CLP 153,836	Average Duration18h 30m	CO₂ emissions 18kg CO₂e
Train	Average PriceCLP 73,182 - CLP 353,926	Average Duration15h 22m	CO₂ emissions 17kg CO₂e

Where are the popular train stations and stops in Prague and Brussels?

Prague

A
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
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B
Praha hl.n
Prague Main Railway Station, 120 00 Praha-Praha 2, Czechia
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C
PRG Airport
Aviatická, 161 08, Praha 6, Czechia
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D
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
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E
Holešovice
Praha-Holešovice, Partyzánská 1546/26, 170 00 Praha 7-Holešovice, Czechia
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F
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic
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Brussels

A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium
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B
Bruxelles / Brussels Central
Brussel-Centraal, Carrefour de l'Europe, 1000 Bruxelles, Belgium

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

04/25

No data

04/26

CLP 198,767

Today

No data

04/28

CLP 154,167

04/29

No data

04/30

CLP 221,982

05/01

No data

05/02

No data

The cheapest trip from Prague to Brussels was searched and found on Apr 28, 2026 with a price of CLP 154,167

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Prague to Brussels, as early as possible.

You can expect to pay from CLP 154,167 to CLP 750,918 for a train ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at CLP 154,167 which is on 2026-04-28.