Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Boston (South Station) | UC Irvine (Crawford Hall) | Cheapest | ||||
 | Bus | Boston (South Station) | Santa Ana Bus Station | Fastest | ||||
| Bus | Boston (South Station) | Anaheim Regional Transportation Intermodal Center | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Boston (South Station) | UC Irvine (Crawford Hall) | No tags | ||||
| Bus | Boston (South Station) | Anaheim Regional Transportation Intermodal Center | No tags |
Last refresh of the prices: Yesterday at 7:02 PM EST.
Get from Boston to Santa Ana
The journey takes about 3 days, 9 hours 30 minutes, and with fares starting at just $318, it presents an excellent value for a comfortable ride.
Where are the popular stops in Boston and Santa Ana?
Stops in Boston
- A145 Dartmouth St, Boston, MA 02116, USA
- B100 Legends Way, Boston, MA 02114, USA
- C335 Grove St, Auburndale, MA 02466
- D
Prudential MBTA Station
220 Huntington Ave, Boston, MA 02115, USA - E
Copley MBTA Station
650 Boylston St, Boston, MA 02116, USA - F
Long Wharf
66 Long Wharf, Boston, MA 02110, USA
Stops in Santa Ana
- A
Santa Ana Greyhound Bus Station
1000 E Santa Ana Blvd, Santa Ana, CA 92701 - B
602 S Main St
602 S Main St, Santa Ana, CA 92701, USA
Compare bus companies
Based on 87517 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $319
Frequently asked questions about travelling from Boston, MA, US to Santa Ana, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Boston to Santa Ana?
The cheapest bus tickets from Boston to Santa Ana start from $318. The average price for this route is around $327. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Boston to Santa Ana?
The average bus travel time from Boston to Santa Ana is 3d 9h, covering a distance of 4154 km. The quickest bus can get you there in 3d 2h and is operated by Greyhound.
Which bus companies service the Boston to Santa Ana route?
Several major bus companies operate on this route with 11 buses available per day.
What are the earliest and latest departure times for the bus from Boston to Santa Ana?
The earliest bus departs from Boston to Santa Ana at 1:30am. And the latest bus departs at 9:50pm.
What are the CO₂ emissions for the bus trip from Boston to Santa Ana?
A bus trip from Boston to Santa Ana generates an estimated 104 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Boston, MA, US to Santa Ana, US was searched and found on Jan 29, 2026 with a price of $312To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Santa Ana, US, as early as possible.
You can expect to pay from $312 to $351 for a bus ticket from Boston, MA, US to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $312 which is on 2026-01-29.
