Bus from Boston, MA, US to Santa Ana, US: Tickets & Schedules

Next bus departures

Next departures for Boston to Santa Ana on January 27
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Boston (South Station)
UC Irvine (Crawford Hall)Cheapest
Greyhound Lines, Inc.Bus
Boston (South Station)
Santa Ana Bus StationFastest
Greyhound Lines, Inc.Bus
Boston (South Station)
Anaheim Regional Transportation Intermodal CenterNo tags
Greyhound Lines, Inc. + FlixBus
Bus
Boston (South Station)
UC Irvine (Crawford Hall)No tags
Greyhound Lines, Inc.Bus
Boston (South Station)
Anaheim Regional Transportation Intermodal CenterNo tags

Last refresh of the prices: Yesterday at 7:02 PM EST.

Get from Boston to Santa Ana

This route is served by bus only

The journey takes about 3 days, 9 hours 30 minutes, and with fares starting at just $318, it presents an excellent value for a comfortable ride.

11bus per day
3d 9hAverage Duration
4154 kmDistance
104kgCO₂ emissions

Frequently asked questions about travelling from Boston, MA, US to Santa Ana, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

  1. How much is the bus ticket from Boston to Santa Ana?

    The cheapest bus tickets from Boston to Santa Ana start from $318. The average price for this route is around $327. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

  2. How long is the bus ride from Boston to Santa Ana?

    The average bus travel time from Boston to Santa Ana is 3d 9h, covering a distance of 4154 km. The quickest bus can get you there in 3d 2h and is operated by Greyhound.

  3. Which bus companies service the Boston to Santa Ana route?

    Several major bus companies operate on this route with 11 buses available per day.

  4. What are the earliest and latest departure times for the bus from Boston to Santa Ana?

    The earliest bus departs from Boston to Santa Ana at 1:30am. And the latest bus departs at 9:50pm.

  5. What are the CO₂ emissions for the bus trip from Boston to Santa Ana?

    A bus trip from Boston to Santa Ana generates an estimated 104 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
01-23
No data
01-24
No data
Today
No data
01-26
No data
01-27
$323
01-28
No data
01-29
$312
01-30
No data
busbud logoThe cheapest trip from Boston, MA, US to Santa Ana, US was searched and found on Jan 29, 2026 with a price of $312

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Santa Ana, US, as early as possible.

You can expect to pay from $312 to $351 for a bus ticket from Boston, MA, US to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $312 which is on 2026-01-29.

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