Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Boston (South Station) | UC Irvine (Crawford Hall) | Cheapest | ||||
 | Bus | Boston (South Station) | Santa Ana Bus Station | Fastest | ||||
| Bus | Boston (South Station) | Anaheim Regional Transportation Intermodal Center | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Boston (South Station) | UC Irvine (Crawford Hall) | No tags | ||||
| Bus | Boston (South Station) | Anaheim Regional Transportation Intermodal Center | No tags |
Last refresh of the prices: Yesterday at 7:02 PM EST.
Get from Boston to Santa Ana
The journey takes about 3 days, 9 hours 30 minutes and with fares starting at just $226, it presents an excellent value for a comfortable ride.
Where are the popular stops in Boston and Santa Ana?
Stops in Boston
- A145 Dartmouth St, Boston, MA 02116, USA
- B100 Legends Way, Boston, MA 02114, USA
- C335 Grove St, Auburndale, MA 02466
- D
Prudential MBTA Station
220 Huntington Ave, Boston, MA 02115, USA - E
Copley MBTA Station
650 Boylston St, Boston, MA 02116, USA - F
Long Wharf
66 Long Wharf, Boston, MA 02110, USA
Stops in Santa Ana
- A
Santa Ana Greyhound Bus Station
1000 E Santa Ana Blvd, Santa Ana, CA 92701 - B
602 S Main St
602 S Main St, Santa Ana, CA 92701, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Boston, MA, US to Santa Ana, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Boston to Santa Ana?
The cheapest bus tickets from Boston to Santa Ana start from $226. The average price for this route is around $233. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Boston to Santa Ana?
The average bus trip duration from Boston to Santa Ana is 3d 9h, covering a distance of 2576 miles (4154 km). The quickest bus can get you there in 3d 2h and is operated by Greyhound.
Which bus companies service the Boston to Santa Ana route?
Several major train operators operate on this route with 11 trains available per day.
What is the earliest and latest departure time for the bus from Boston to Santa Ana?
The earliest bus departs from Boston to Santa Ana at 1:30am. And the latest bus departs at 9:50pm.
What are the CO₂ emissions for the bus trip from Boston to Santa Ana?
A bus trip from Boston to Santa Ana generates an estimated 104 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Boston, MA, US to Santa Ana, US was searched and found on Jan 29, 2026 with a price of $222To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Santa Ana, US, as early as possible.
You can expect to pay from $222 to $249 for a bus ticket from Boston, MA, US to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $222 which is on 2026-01-29.
