Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Brussels North Train Station | Santander (Estacion de Autobuses) | Cheapest | ||||
| Bus | Brussels South (Gare du Midi) | Santander (Estacion de Autobuses) | Fastest | ||||
| Bus | Brussels Airport | Santander (Estacion de Autobuses) | No tags |
Last refresh of the prices: 2025-12-08 CET.
Get from Brussels to Santander
The journey takes about 19 hours 20 minutes, and with fares starting at just $95, it presents an excellent value for a comfortable ride.
Where are the popular stops in Brussels and Santander?
Stops in Brussels
- ARue de France 85, 1060 Saint-Gilles, Belgium
- BBoulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
- CPachecolaan 5, 1000 Brussel, Belgium
- D
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium
Stops in Santander
- ACalle Navas de Tolosa, 2, 39002 Santander, Cantabria, Spain
- C
Av. de los Castros 43A
Av. de los Castros 43A, 39005 Santander, Cantabria, Spain - D
Calle Camarreal-Ojaiz
Calle Camarreal-Ojaiz, 52, 39011 Santander, Cantabria, Spain - E
Av. de Pontejos
Av. de Pontejos, 33A, 39005 Santander, Cantabria, Spain - F
Estación Marítima
39002 Santander, Cantabria, Spain
Compare bus companies
Based on 11617 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $95
Frequently asked questions about travelling from Brussels to Santander by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Brussels to Santander?
The cheapest bus tickets from Brussels to Santander start from $95. The average price for this route is around $118. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Brussels to Santander?
The average bus travel time from Brussels to Santander is 19h 20m, covering a distance of 1025 km. The quickest bus can get you there in 18h 10m and is operated by FlixBus.
Which bus companies service the Brussels to Santander route?
Several major bus companies operate on this route with 3 buses available per day.
What are the earliest and latest departure times for the bus from Brussels to Santander?
The earliest bus departs from Brussels to Santander at 9:45am. And the latest bus departs at 3:10pm.
What are the CO₂ emissions for the bus trip from Brussels to Santander?
A bus trip from Brussels to Santander generates an estimated 26 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Brussels to Santander was searched and found on Dec 15, 2025 with a price of $90To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Brussels to Santander, as early as possible.
