Bus Tickets from Charleston, SC, US to Jacksonville, FL

Find affordable bus tickets from Charleston, SC, US to Jacksonville, FL with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayJul 23
from US$50
TomorrowJul 24
from US$50
FriJul 25
from US$54
SatJul 26
from US$50
SunJul 27
from US$54
MonJul 28
from US$50
TueJul 29
from US$50
WedJul 30
from US$50

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: July 24 at
    Departure city: Charleston
    Departure location: 4565 Gaynor Ave, North Charleston
    Arrival time: July 24 at
    Destination city: Jacksonville
    Destination location: Jacksonville Bus Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

Last refresh of the prices: Today at 5:00 AM EDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Charleston to Jacksonville

Bus
Average PriceUS$44 - US$89Average Duration5h 5m
8kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$51 - US$166Average Duration4h 28m
29kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Charleston to Jacksonville

Among the sustainable travel choices, the train stands out as a good way to reach Jacksonville. The journey takes about 4 hours 28 minutes, and with fares starting at just US$51, it presents an excellent value for a comfortable ride.

1train per day
4h 28mAverage Duration
US$51Cheapest ticket
29kgCO₂ emissions

Bus Charleston, SC, US to Jacksonville, FL: Trip Overview

Average Ticket PriceUS$46
Average Bus Trip Duration5h 5m
Number of daily buses1
Earliest bus departure3:15pm
Distance324 km

Charleston to Jacksonville Bus

Busbud helps you find a bus from Charleston to Jacksonville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Charleston to Jacksonville will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Charleston to Jacksonville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Charleston, SC, US - Jacksonville, FL

  1. What is the distance between Charleston and Jacksonville?

    It's about 318 km (198 miles) from Charleston to Jacksonville.

  2. What are the departure and arrival locations for buses traveling from Charleston to Jacksonville?

    Buses departing from Charleston Bus Station in Charleston will take you to Jacksonville Amtrak Station in Jacksonville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07-21
US$43
07-22
US$38
Today
US$42
07-24
US$42
07-25
US$46
07-26
US$42
07-27
US$46
07-28
US$42
busbud logoThe cheapest trip from Charleston, SC, US to Jacksonville, FL was searched and found on Jul 22, 2025 with a price of US$38

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Charleston, SC, US to Jacksonville, FL, as early as possible.

You can expect to pay from US$38 to US$46 for a bus ticket from Charleston, SC, US to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at US$42 which is on 2025-07-24.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Charleston and Jacksonville!

Much more than a mere vehicle taking you from Charleston to Jacksonville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Charleston to Jacksonville that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Charleston to Jacksonville while indulging in miles on end of beautiful scenic views.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

What's the cheapest way to go from Charleston, SC, US to Jacksonville, FL?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Charleston, SC, US by bus?

Bus from Charleston, SC, US to Jacksonville, FL

You can also go to Jacksonville, FL by train

Train from Charleston, SC, US to Jacksonville, FL

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

People from around the world trust Busbud

‌

Popular Buses Connecting Charleston

Buses Leaving from Charleston

Buses Going to Charleston

Popular Buses Connecting Jacksonville

Buses Leaving from Jacksonville

Buses Going to Jacksonville