Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Bus station | 1116 Woodruff Rd | CheapestFastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Florence, SC | 1116 Woodruff Rd | No tags |
Last refresh of the prices: Last Monday at 10:46 AM EST.
Compare 2 ways to go from Florence to Greenville
Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 5 hours 55 minutes, and with fares starting at just $114, it presents an excellent value for a comfortable ride.
Where are the popular stops in Florence and Greenville?
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Compare bus companies
Based on 11524 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $114
Frequently asked questions about travelling from Florence, SC, US to Greenville, SC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Florence to Greenville?
The cheapest bus tickets from Florence to Greenville start from $114. The average price for this route is around $171. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Greenville?
The average bus travel time from Florence to Greenville is 5h 55m, covering a distance of 244 km. The quickest bus can get you there in 5h 55m and is operated by FlixBus.
Which bus companies service the Florence to Greenville route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from Florence to Greenville?
The earliest bus departs from Florence to Greenville at 12:05am. And the latest bus departs at 1:45pm.
What are the CO₂ emissions for the bus trip from Florence to Greenville?
A bus trip from Florence to Greenville generates an estimated 6 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Greenville, SC was searched and found on Dec 8, 2025 with a price of $215To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Greenville, SC, as early as possible.
You can expect to pay from $215 to $215 for a bus ticket from Florence, SC, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $215 which is on 2025-12-08.
What's the cheapest way to go from Florence, SC, US to Greenville, SC?
The bus is the cheapest travel choice for this destination
